Microtubule's conformational cap

D. Chretien, I. Janosi, J.C. Taveau, H. Flyvbjerg

    Research output: Contribution to journalConference articlepeer-review

    Abstract

    The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.
    Original languageEnglish
    JournalCell Structure and Function
    Volume24
    Issue number5
    Pages (from-to)299-303
    ISSN0386-7196
    DOIs
    Publication statusPublished - 1999
    Event International Symposium on Tubulin 30 Years Later, at the 42nd NIBB (National Institute for Basic Biology) Conference - Okazaki, Japan
    Duration: 24 Feb 199926 Feb 1999

    Conference

    Conference International Symposium on Tubulin 30 Years Later, at the 42nd NIBB (National Institute for Basic Biology) Conference
    Country/TerritoryJapan
    CityOkazaki
    Period24/02/199926/02/1999

    Keywords

    • Microtubule
    • Tubulin
    • Electron microscopy
    • Computer modelling

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