Microtubule's conformational cap

D. Chretien; I. Janosi; J.C. Taveau; H. Flyvbjerg

doi:10.1247/csf.24.299

Microtubule's conformational cap

D. Chretien, I. Janosi, J.C. Taveau, H. Flyvbjerg

Research output: Contribution to journal › Conference article › Research › peer-review

Abstract

The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.

Original language	English
Journal	Cell Structure and Function
Volume	24
Issue number	5
Pages (from-to)	299-303
ISSN	0386-7196
DOIs	https://doi.org/10.1247/csf.24.299
Publication status	Published - 1999
Event	42nd National Institute for Basic Biology Conference: International Symposium on Tubulin 30 Years Later - Okazaki, Japan Duration: 24 Feb 1999 → 26 Feb 1999 Conference number: 42

Conference

Conference	42nd National Institute for Basic Biology Conference
Number	42
Country/Territory	Japan
City	Okazaki
Period	24/02/1999 → 26/02/1999

Keywords

Microtubule
Tubulin
Electron microscopy
Computer modelling

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title = "Microtubule's conformational cap",

abstract = "The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called {"}GTP-cap{"}. Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed. ",

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author = "D. Chretien and I. Janosi and J.C. Taveau and H. Flyvbjerg",

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journal = "Cell Structure and Function",

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T1 - Microtubule's conformational cap

AU - Chretien, D.

AU - Janosi, I.

AU - Taveau, J.C.

AU - Flyvbjerg, H.

N1 - Conference code: 42

PY - 1999

Y1 - 1999

N2 - The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.

AB - The molecular mechanisms that allow elongation of the unstable microtubule lattice remain unclear. It is usually thought that the GDP-liganded tubulin lattice is capped by a small layer of GTP- or GDP-P(i)-liganded molecules, the so called "GTP-cap". Here, we point-out that the elastic properties of the microtubule lattice cause a difference in stability between the elongating tubulin sheet and the completed microtubule wall. The implications of our observations for microtubule structure and dynamics are discussed.

KW - Nye funktionelle materialer

KW - Microtubule

KW - Tubulin

KW - Electron microscopy

KW - Computer modelling

U2 - 10.1247/csf.24.299

DO - 10.1247/csf.24.299

M3 - Conference article

VL - 24

SP - 299

EP - 303

JO - Cell Structure and Function

JF - Cell Structure and Function

SN - 0386-7196

IS - 5

T2 - 42nd National Institute for Basic Biology Conference

Y2 - 24 February 1999 through 26 February 1999

ER -

Microtubule's conformational cap

Abstract

Conference

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