MicroRNA Expression during Viral Infection or PolyI:C Stimulation in a Fish Model

Lasse Bøgelund Juel Kristensen, Brian Dall Schyth, Niels Lorenzen, Finn Skou Pedersen

    Research output: Contribution to conferencePosterResearch

    Abstract

    Fish are important as small vertebrate models for studying various aspects of development and disease. MicroRNA regulation in fish has so far received attention especially in studies of their expression and function during embryonic development. In the studies carried out at the National Veterinary Institute in Århus we aim at using fish models for studying microRNA regulation during viral infection. In the studies presented here we make use of a qPCR method to detect miRNAs in fish cells. We present results regarding the expression of the immunologically relevant microRNAs, miR-155, miR-146a and miR-146b in fish cells during infection with the fish pathogenic virus viral hemorrhagic septicemia virus (VHSV) and during immune stimulation with double stranded RNA (polyI:C). We highlight the need of finding stable normalization genes for microRNA detection.
    Original languageEnglish
    Publication date2009
    Publication statusPublished - 2009
    EventMicroRNA : MicroRNA research results, technology insights and networking - The Biotech Research & Innovation Centre (BIRC), Copenhagen
    Duration: 1 Jan 2009 → …
    Conference number: 1

    Conference

    ConferenceMicroRNA : MicroRNA research results, technology insights and networking
    Number1
    CityThe Biotech Research & Innovation Centre (BIRC), Copenhagen
    Period01/01/2009 → …

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