MicroRNA 486-3P as a stability marker in acute coronary syndrome

Tianling Wei, Lasse Folkersen, Ewa Ehrenborg, Anders Gabrielsen

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    Abstract

    Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).
    Original languageEnglish
    Article numbere00351
    JournalBioscience Reports
    Volume36
    Issue number3
    Number of pages5
    ISSN0144-8463
    DOIs
    Publication statusPublished - 2016

    Bibliographical note

    This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution
    Licence 4.0 (CC BY).

    Keywords

    • Coronary artery disease
    • Diagnosis biomarker
    • MicroRNA

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