Abstract
Easily accessible biomarkers are needed to diagnose cardiovascular disease precisely-particularly, to distinguish between disease subtypes that are encountered in clinical practice. Per the hypothesis that plasma miRNA is valuable for this purpose, we performed complete transcriptional profiling of an miRNA discovery-set in 14 samples: three patients with ST-elevated acute myocardial infarction (STEMI) at baseline and after three months of follow-up, four with stable ischaemic heart disease (stable-IHD) and four healthy age-matched volunteers. Our aim was to determine whether we could distinguish patients with unstable plaques from stable patients following a STEMI event. After analysing miRNA profiles, we conducted a validation study comparing three-month STEMI (n=40) with stable-IHD (n=35), which confirmed that miR-486-3P differentiates patients with three-month STEMI from those with stable-IHD (P=0.019).
Original language | English |
---|---|
Article number | e00351 |
Journal | Bioscience Reports |
Volume | 36 |
Issue number | 3 |
Number of pages | 5 |
ISSN | 0144-8463 |
DOIs | |
Publication status | Published - 2016 |
Bibliographical note
This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons AttributionLicence 4.0 (CC BY).
Keywords
- Coronary artery disease
- Diagnosis biomarker
- MicroRNA