Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Tanja Thorskov Bladt; Sivan Kalifa-Aviv; Thomas Ostenfeld Larsen; Shmuel Carmeli

doi:10.1016/j.tet.2013.12.009

Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Tanja Thorskov Bladt, Sivan Kalifa-Aviv, Thomas Ostenfeld Larsen, Shmuel Carmeli

Tel Aviv University

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.

Original language	English
Journal	Tetrahedron
Volume	70
Issue number	4
Pages (from-to)	936-943
ISSN	0040-4020
DOIs	https://doi.org/10.1016/j.tet.2013.12.009
Publication status	Published - 2014

Keywords

VDRVASLKQYDDQG-DHBDMACVSA-N
UDOWEWNWQMROSG-LUWZMBIGSA-N
OOPLGLFZVDBGII-LTQWVOCPSA-N

Access to Document

10.1016/j.tet.2013.12.009

OpenUrl availability

Full text

Cite this

@article{0f860922df9841649a8a91890229557d,

title = "Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel",

abstract = "Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.",

keywords = "VDRVASLKQYDDQG-DHBDMACVSA-N, UDOWEWNWQMROSG-LUWZMBIGSA-N, OOPLGLFZVDBGII-LTQWVOCPSA-N",

author = "Bladt, {Tanja Thorskov} and Sivan Kalifa-Aviv and Larsen, {Thomas Ostenfeld} and Shmuel Carmeli",

year = "2014",

doi = "10.1016/j.tet.2013.12.009",

language = "English",

volume = "70",

pages = "936--943",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Pergamon Press",

number = "4",

}

TY - JOUR

T1 - Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

AU - Bladt, Tanja Thorskov

AU - Kalifa-Aviv, Sivan

AU - Larsen, Thomas Ostenfeld

AU - Carmeli, Shmuel

PY - 2014

Y1 - 2014

N2 - Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.

AB - Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.

KW - VDRVASLKQYDDQG-DHBDMACVSA-N

KW - UDOWEWNWQMROSG-LUWZMBIGSA-N

KW - OOPLGLFZVDBGII-LTQWVOCPSA-N

U2 - 10.1016/j.tet.2013.12.009

DO - 10.1016/j.tet.2013.12.009

M3 - Journal article

SN - 0040-4020

VL - 70

SP - 936

EP - 943

JO - Tetrahedron

JF - Tetrahedron

IS - 4

ER -

Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Abstract

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this