Micropeptins from Microcystis sp. collected in Kabul Reservoir, Israel

Tanja Thorskov Bladt, Sivan Kalifa-Aviv, Thomas Ostenfeld Larsen, Shmuel Carmeli

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Three new micropeptins, micropeptin KR1030, KR1002 and KR998 and the known microcyclamide GL546A were isolated from the extract of Microcystis sp. bloom material collected in Kabul Reservoir, Israel. The planar structures of the compounds were determined by homonuclear and inverse-heteronuclear 2D-NMR techniques as well as high-resolution mass spectrometry. The absolute configuration of the asymmetric centres of the amino acids was studied using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin and elastase.
    Original languageEnglish
    JournalTetrahedron
    Volume70
    Issue number4
    Pages (from-to)936-943
    ISSN0040-4020
    DOIs
    Publication statusPublished - 2014

    Keywords

    • VDRVASLKQYDDQG-DHBDMACVSA-N
    • UDOWEWNWQMROSG-LUWZMBIGSA-N
    • OOPLGLFZVDBGII-LTQWVOCPSA-N

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