Microorganisms for the production of melatonin

Eric Michael Knight (Inventor), Jiangfeng Zhu (Inventor), Jochen Förster (Inventor), Hao Luo (Inventor)

Research output: Patent

314 Downloads (Pure)


Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L- tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O- methyltransferase; an L-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described.
Original languageEnglish
IPCC12N1/21; C12N15/53; C12N15/54
Patent numberWO2013127915
Filing date06/09/2013
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date29/02/2012
Priority numberEP20120157542
Publication statusPublished - 2013

Bibliographical note

Also published as: US2015024440 (A1); EP2820121 (A1)


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