Abstract
Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5-hydroxy-L- tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O- methyltransferase; an L-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and means for providing tetrahydrobiopterin (THB). Related sequences and vectors for use in preparing such recombinant microbial cells are also described.
| Original language | English |
|---|---|
| IPC | C12N1/21; C12N15/53; C12N15/54 |
| Patent number | WO2013127915 |
| Filing date | 06/09/2013 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 29/02/2012 |
| Priority number | EP20120157542 |
| Publication status | Published - 2013 |