Microorganisms for efficient production of melatonin and related compounds.

Jiangfeng Zhu (Inventor), Niels Bjerg Jensen (Inventor), Xiao Chen (Inventor), Jochen Förster (Inventor), Irina Borodina (Inventor)

Research output: Patent

84 Downloads (Pure)

Abstract

Recombinant microbial cells and methods for producing 5HTP, melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an L-tryptophan hydroxylase, a 5- hydroxy-L-tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin O- methyltransferase; and means for providing tetrahydrobiopterin (THB), and can be further genetically modified to enrich one or more of tryptophan, S-adenosyl-L-methinonine and acetyl coenzyme A. Related sequences and vectors for use in preparing such recombinant microbial cells are also described.

Original languageEnglish
IPCC12P 17/ 10 A I
Patent numberWO2015032911
Filing date12/03/2015
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date05/09/2013
Priority numberEP20130183120
Publication statusPublished - 12 Mar 2015

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