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Abstract

Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these) towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance.
Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume138
Pages (from-to)41-55
Number of pages15
ISSN0169-409X
DOIs
Publication statusPublished - 2019

Keywords

  • Micromotors
  • Drug delivery in vivo
  • GI tract
  • Solid tumor
  • External trigger actuation

Cite this

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title = "Micromotors for drug delivery in vivo: The road ahead",
abstract = "Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these) towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance.",
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author = "Srivastava, {Sarvesh Kumar} and Gael Clergeaud and Andresen, {Thomas L.} and Anja Boisen",
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pages = "41--55",
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Micromotors for drug delivery in vivo: The road ahead. / Srivastava, Sarvesh Kumar; Clergeaud, Gael; Andresen, Thomas L.; Boisen, Anja.

In: Advanced Drug Delivery Reviews, Vol. 138, 2019, p. 41-55.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - Micromotors for drug delivery in vivo: The road ahead

AU - Srivastava, Sarvesh Kumar

AU - Clergeaud, Gael

AU - Andresen, Thomas L.

AU - Boisen, Anja

PY - 2019

Y1 - 2019

N2 - Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these) towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance.

AB - Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these) towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance.

KW - Micromotors

KW - Drug delivery in vivo

KW - GI tract

KW - Solid tumor

KW - External trigger actuation

U2 - 10.1016/j.addr.2018.09.005

DO - 10.1016/j.addr.2018.09.005

M3 - Journal article

VL - 138

SP - 41

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JO - Advanced Drug Delivery Reviews

JF - Advanced Drug Delivery Reviews

SN - 0169-409X

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