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Abstract

Autonomously propelled/externally guided micromotors overcome current drug delivery challenges by providing (a) higher drug loading capacity, (b) localized delivery (less toxicity), (c) enhanced tissue penetration and (d) active maneuvering in vivo. These microscale drug delivery systems can exploit biological fluids as well as exogenous stimuli, like light-NIR, ultrasound and magnetic fields (or a combination of these) towards propulsion/drug release. Ability of these wireless drug carriers towards localized targeting and controlled drug release, makes them a lucrative candidate for drug administration in complex microenvironments (like solid tumors or gastrointestinal tract). In this report, we discuss these microscale drug delivery systems for their therapeutic benefits under in vivo setting and provide a design-application rationale towards greater clinical significance.
Original languageEnglish
JournalAdvanced Drug Delivery Reviews
Volume138
Pages (from-to)41-55
Number of pages15
ISSN0169-409X
DOIs
Publication statusPublished - 2019

Keywords

  • Micromotors
  • Drug delivery in vivo
  • GI tract
  • Solid tumor
  • External trigger actuation

Projects

COFUNDfellowsDTU: COFUNDfellowsDTU

Brodersen, S. W. & Præstrud, M. R.

01/01/201731/12/2022

Project: Research

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