Micromechanical sensors for the measurement of biopolymer degradation

Stephan Sylvest Keller, Lene Gammelgaard, M P Jensen, Silvan Schmid, Zachary James Davis, Anja Boisen

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    We present microcantilever-based sensors for the characterization of biopolymer degradation by enzymes. Thin films of Poly(L-lactide) (PLLA) were spray-coated onto SU-8 cantilevers with well-known material properties and dimensions. The micromechanical sensors were immersed in solutions of proteinase K to investigate enzymatic degradation of PLLA. A decrease of the resonance frequency after immersion indicated degradation of the biopolymer coating and allowed the estimation of the degradation rate at a specific enzyme concentration.
    Original languageEnglish
    Title of host publicationIEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS)
    PublisherIEEE
    Publication date2011
    ISBN (Print)978-1-4244-9632-7
    DOIs
    Publication statusPublished - 2011
    Event24th International Conference on Micro Electro Mechanical Systems - Hilton Cancun Golf & Spa Resort, Cancun, Mexico
    Duration: 23 Jan 201127 Jan 2011
    Conference number: 24
    http://www.ieee-mems2011.org/

    Conference

    Conference24th International Conference on Micro Electro Mechanical Systems
    Number24
    LocationHilton Cancun Golf & Spa Resort
    Country/TerritoryMexico
    CityCancun
    Period23/01/201127/01/2011
    Internet address

    Keywords

    • SU-8 cantilevers
    • POLY(L-lactide) thin films
    • Micromechanical sensors
    • Spray coating
    • Microcantilever-based sensors
    • Immersion
    • Biopolymer degradation
    • Biopolymer coating
    • Poteinase K
    • Enzymes
    • Resonance frequency

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