Micromechanical sensors for the measurement of biopolymer degradation

Stephan Sylvest Keller, Lene Gammelgaard, M P Jensen, Silvan Schmid, Zachary James Davis, Anja Boisen

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    Abstract

    We present microcantilever-based sensors for the characterization of biopolymer degradation by enzymes. Thin films of Poly(L-lactide) (PLLA) were spray-coated onto SU-8 cantilevers with well-known material properties and dimensions. The micromechanical sensors were immersed in solutions of proteinase K to investigate enzymatic degradation of PLLA. A decrease of the resonance frequency after immersion indicated degradation of the biopolymer coating and allowed the estimation of the degradation rate at a specific enzyme concentration.
    Original languageEnglish
    Title of host publicationIEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS)
    PublisherIEEE
    Publication date2011
    ISBN (Print)978-1-4244-9632-7
    DOIs
    Publication statusPublished - 2011
    Event24th International Conference on Micro Electro Mechanical Systems - Hilton Cancun Golf & Spa Resort, Cancun, Mexico
    Duration: 23 Jan 201127 Jan 2011
    Conference number: 24
    http://www.ieee-mems2011.org/

    Conference

    Conference24th International Conference on Micro Electro Mechanical Systems
    Number24
    LocationHilton Cancun Golf & Spa Resort
    CountryMexico
    CityCancun
    Period23/01/201127/01/2011
    Internet address

    Keywords

    • SU-8 cantilevers
    • POLY(L-lactide) thin films
    • Micromechanical sensors
    • Spray coating
    • Microcantilever-based sensors
    • Immersion
    • Biopolymer degradation
    • Biopolymer coating
    • Poteinase K
    • Enzymes
    • Resonance frequency

    Cite this

    Keller, S. S., Gammelgaard, L., Jensen, M. P., Schmid, S., Davis, Z. J., & Boisen, A. (2011). Micromechanical sensors for the measurement of biopolymer degradation. In IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS) IEEE. https://doi.org/10.1109/MEMSYS.2011.5734460
    Keller, Stephan Sylvest ; Gammelgaard, Lene ; Jensen, M P ; Schmid, Silvan ; Davis, Zachary James ; Boisen, Anja. / Micromechanical sensors for the measurement of biopolymer degradation. IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2011.
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    title = "Micromechanical sensors for the measurement of biopolymer degradation",
    abstract = "We present microcantilever-based sensors for the characterization of biopolymer degradation by enzymes. Thin films of Poly(L-lactide) (PLLA) were spray-coated onto SU-8 cantilevers with well-known material properties and dimensions. The micromechanical sensors were immersed in solutions of proteinase K to investigate enzymatic degradation of PLLA. A decrease of the resonance frequency after immersion indicated degradation of the biopolymer coating and allowed the estimation of the degradation rate at a specific enzyme concentration.",
    keywords = "SU-8 cantilevers, POLY(L-lactide) thin films, Micromechanical sensors, Spray coating, Microcantilever-based sensors, Immersion, Biopolymer degradation, Biopolymer coating, Poteinase K, Enzymes, Resonance frequency",
    author = "Keller, {Stephan Sylvest} and Lene Gammelgaard and Jensen, {M P} and Silvan Schmid and Davis, {Zachary James} and Anja Boisen",
    year = "2011",
    doi = "10.1109/MEMSYS.2011.5734460",
    language = "English",
    isbn = "978-1-4244-9632-7",
    booktitle = "IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS)",
    publisher = "IEEE",
    address = "United States",

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    Keller, SS, Gammelgaard, L, Jensen, MP, Schmid, S, Davis, ZJ & Boisen, A 2011, Micromechanical sensors for the measurement of biopolymer degradation. in IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 24th International Conference on Micro Electro Mechanical Systems, Cancun, Mexico, 23/01/2011. https://doi.org/10.1109/MEMSYS.2011.5734460

    Micromechanical sensors for the measurement of biopolymer degradation. / Keller, Stephan Sylvest; Gammelgaard, Lene; Jensen, M P; Schmid, Silvan; Davis, Zachary James; Boisen, Anja.

    IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2011.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

    TY - GEN

    T1 - Micromechanical sensors for the measurement of biopolymer degradation

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    AU - Boisen, Anja

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    N2 - We present microcantilever-based sensors for the characterization of biopolymer degradation by enzymes. Thin films of Poly(L-lactide) (PLLA) were spray-coated onto SU-8 cantilevers with well-known material properties and dimensions. The micromechanical sensors were immersed in solutions of proteinase K to investigate enzymatic degradation of PLLA. A decrease of the resonance frequency after immersion indicated degradation of the biopolymer coating and allowed the estimation of the degradation rate at a specific enzyme concentration.

    AB - We present microcantilever-based sensors for the characterization of biopolymer degradation by enzymes. Thin films of Poly(L-lactide) (PLLA) were spray-coated onto SU-8 cantilevers with well-known material properties and dimensions. The micromechanical sensors were immersed in solutions of proteinase K to investigate enzymatic degradation of PLLA. A decrease of the resonance frequency after immersion indicated degradation of the biopolymer coating and allowed the estimation of the degradation rate at a specific enzyme concentration.

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    KW - POLY(L-lactide) thin films

    KW - Micromechanical sensors

    KW - Spray coating

    KW - Microcantilever-based sensors

    KW - Immersion

    KW - Biopolymer degradation

    KW - Biopolymer coating

    KW - Poteinase K

    KW - Enzymes

    KW - Resonance frequency

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    Keller SS, Gammelgaard L, Jensen MP, Schmid S, Davis ZJ, Boisen A. Micromechanical sensors for the measurement of biopolymer degradation. In IEEE 24. International Conference on Micro Electro Mechanical Systems (MEMS). IEEE. 2011 https://doi.org/10.1109/MEMSYS.2011.5734460