Microfluidics-based Single Cell Analytical Platforms for Characterization of Cancer

Research output: Chapter in Book/Report/Conference proceedingBook chapter – Annual report year: 2016Researchpeer-review

Without internal affiliation

  • Author: Kristoffersen, Emil Laust

    Aarhus University, Denmark

  • Author: Jepsen, Morten Leth

    Aarhus University

  • Author: Knudsen, Birgitta R.

    Aarhus University, Denmark

  • Author: Ho, Yi Ping

    Aarhus University, Denmark

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Cells are defined as the basic functional unit of living organisms. They sense environmental stimuli, respond and adapt to the environmental changes chemically or physically in order to form and maintain the distinct tissues in complex biological organisms. Therefore, even cells of identical genetic identities can display a wide disparity of physical responses (such as cell morphologies) or chemical responses (such as RNA or protein expression level regulation). These asynchronous responses to the microenvironments, often due to random fl uctuations, or noise in gene especially when techniques with single cell sensitivity are not available. Hence, currently our understanding of cells are in many aspects limited by the inherent ensemble average obtained by analyzing bulk populations of cells, which does not necessary precisely represent the individual behavior of each cell within a population.
Original languageEnglish
Title of host publicationNanomedicine
EditorsKenneth A. Howard, Thomas Vorup-Jensen, Dan Peer
PublisherSpringer
Publication date2016
Pages77-95
Chapter5
ISBN (Print)978-1-4939-3632-8
ISBN (Electronic) 978-1-4939-3634-2
DOIs
Publication statusPublished - 2016
Externally publishedYes
SeriesAdvances in Delivery Science and Technology
ISSN2192-6212
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Nanosensors, Circulating tumor cells, Genomic analysis, Enzymatic activities

ID: 140594127