Microfluidic very large-scale integration for biochips: Technology, testing and fault-tolerant design

Ismail Emre Araci, Paul Pop, Krishnendu Chakrabarty

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


Microfluidic biochips are replacing the conventional biochemical analyzers by integrating all the necessary functions for biochemical analysis using microfluidics. Biochips are used in many application areas, such as, in vitro diagnostics, drug discovery, biotech and ecology. The focus of this paper is on continuous-flow biochips, where the basic building block is a microvalve. By combining these microvalves, more complex units such as mixers, switches, multiplexers can be built, hence the name of the technology, “microfluidic Very Large-Scale Integration” (mVLSI). A roadblock in the deployment of microfluidic biochips is their low reliability and lack of test techniques to screen defective devices before they are used for biochemical analysis. Defective chips lead to repetition of experiments, which is undesirable due to high reagent cost and limited availability of samples. This paper presents the state-of-the-art in the mVLSI platforms and emerging research challenges in the area of continuous-flow microfluidics, focusing on testing techniques and fault-tolerant design.
Original languageEnglish
Title of host publicationProceedings of 20th IEEE European Test Symposium (ETS)
Number of pages8
Publication date2015
ISBN (Print)978-1-4799-7603-4
Publication statusPublished - 2015
Event20th IEEE European Test Symposium (ETS) - Grand Hotel Italia, Cluj-Napoca, Romania
Duration: 25 May 201529 May 2015


Conference20th IEEE European Test Symposium (ETS)
LocationGrand Hotel Italia
Internet address

Cite this

Araci, I. E., Pop, P., & Chakrabarty, K. (2015). Microfluidic very large-scale integration for biochips: Technology, testing and fault-tolerant design. In Proceedings of 20th IEEE European Test Symposium (ETS) IEEE. https://doi.org/10.1109/ETS.2015.7138736