MICROFLUIDIC DEVICE POSSESSING STRUCTURES ENABLING DIFFERENTIAL ANALYSIS OF A SINGLE CELL'S CONSTITUENTS

Jan Pieter Van Der Zaag (Inventor), Rodolphe Marie (Inventor), Wilhelmina VAN STRIJP (Inventor), Tom Olesen (Inventor), Martinus Vulders (Inventor), Anders Kristensen (Inventor)

    Research output: Patent

    108 Downloads (Pure)

    Abstract

    A method and a micro fluidic device comprising at least one micro fluidic structure for differential extraction of nuclear and extra-nuclear constituents of a single cell, said micro fluidic structure comprising a feeding channel for receiving a volume of a sample containing at least one cell, at least one trapping structure for capturing a single cell, and at least one output channel in fluid connection with the at least one trapping structure, wherein the at least one trapping structure extends from one side of the feeding channel substantially perpendicular to longitudinal axis of the feeding channel, the at least one trapping structure possessing an aperture at its end opposite to the fluid channel and in fluid communication with an output channel, said aperture being configured to provide a narrow section such that the nucleus of a cell captured in the trapping structure cannot pass through said narrow section into the output channel.

    Original languageEnglish
    IPCB01L 3/ 00 A I
    Patent numberWO2017085032
    Filing date26/05/2017
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date20/11/2015
    Priority numberEP20150195604
    Publication statusPublished - 26 May 2017

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