Abstract
A Microfluidic chip (100) for transmission electron microscopy has a monolithic body (101) with a front side (102) and a back side (103). The monolithic body (101) comprises an opening (104) on the back side (103) extending in a vertical direction from the back side (103) to a membrane (107) on the front side (102), the membrane (107) being supported at edges (106) of the opening (104) and extending across the opening (104), and a microfluidic channel (110, 610, 710a/b) comprising on top of the membrane (107) a sample chamber (113, 413, 713) with a top window (117, 417, 717) towards the front side (102) and a bottom window (116, 416, 716) towards the back side (103), the top and bottom windows (117, 417, 717 / 116, 416, 716) being aligned with each other so as to allow for observation of a sample volume between the top and bottom windows (117, 417, 717 / 116, 416, 716) inside the sample chamber (113, 413, 713) in a transmission configuration along an axial direction (EO), wherein the dimension of the membrane (107) in at least one horizontal direction exceeds the dimension of the sample chamber (113, 413, 713) in that direction.
| Original language | English |
|---|---|
| IPC | G01N23/04 |
| Patent number | EP2626884 |
| Filing date | 14/08/2013 |
| Country/Territory | Denmark |
| Publication status | Published - 2013 |