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Abstract
Among all the drug administration routes, the oral one is the most preferred by the patients being less invasive, faster and easier.
Oral drug delivery systems designed to target the intestine are produced by powder technology and capsule formulations. Those systems including micro- and nano-particulate systems (i.e. vesicles, polymer nanoparticles, dendrimers etc.) suffer the non-unidirectional release of the drug to the epithelium of the intestine, which entails an inevitable loss in the lumen and, therefore, the reduction of the drug delivered to the intestinal epithelium. A new promising approach focuses on reservoir based microdevices serving as carriers for poorly soluble drugs, hereby called microcontainers (1).
Microcontainers have a cylindrical geometry and provide a unidirectional release due to their design meanwhile protecting the drug formulation from the low gastric pH and the enzymatic degradation. Here, we present the preparation of microcontainers with enteric coating (2) efficiently loaded with drug and able to target the intestine as a multi-particulate system.
Oral drug delivery systems designed to target the intestine are produced by powder technology and capsule formulations. Those systems including micro- and nano-particulate systems (i.e. vesicles, polymer nanoparticles, dendrimers etc.) suffer the non-unidirectional release of the drug to the epithelium of the intestine, which entails an inevitable loss in the lumen and, therefore, the reduction of the drug delivered to the intestinal epithelium. A new promising approach focuses on reservoir based microdevices serving as carriers for poorly soluble drugs, hereby called microcontainers (1).
Microcontainers have a cylindrical geometry and provide a unidirectional release due to their design meanwhile protecting the drug formulation from the low gastric pH and the enzymatic degradation. Here, we present the preparation of microcontainers with enteric coating (2) efficiently loaded with drug and able to target the intestine as a multi-particulate system.
Original language | English |
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Publication date | 2016 |
Number of pages | 2 |
Publication status | Published - 2016 |
Event | 11th Central European Symposium on Pharmaceutical Technology - University of Belgrade, Belgrade, Serbia Duration: 22 Sept 2016 → 24 Sept 2016 Conference number: 11 http://sphu.org/en/the-11th-central-european-symposium-on-pharmaceutical-technology.html |
Conference
Conference | 11th Central European Symposium on Pharmaceutical Technology |
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Number | 11 |
Location | University of Belgrade |
Country/Territory | Serbia |
City | Belgrade |
Period | 22/09/2016 → 24/09/2016 |
Internet address |
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Dive into the research topics of 'Microcontainers for Intestinal Drug Delivery'. Together they form a unique fingerprint.Activities
- 1 Conference presentations
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11th Central European Symposium on Pharmaceutical Technology
Tentor, F. (Speaker)
23 Sept 2016 → 24 Sept 2016Activity: Talks and presentations › Conference presentations
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