Microcontainers for Intestinal Drug Delivery

Fabio Tentor, Chiara Mazzoni, Stephan Sylvest Keller, Paolo Marizza, Anja Boisen

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    Abstract

    Among all the drug administration routes, the oral one is the most preferred by the patients being less invasive, faster and easier.
    Oral drug delivery systems designed to target the intestine are produced by powder technology and capsule formulations. Those systems including micro- and nano-particulate systems (i.e. vesicles, polymer nanoparticles, dendrimers etc.) suffer the non-unidirectional release of the drug to the epithelium of the intestine, which entails an inevitable loss in the lumen and, therefore, the reduction of the drug delivered to the intestinal epithelium. A new promising approach focuses on reservoir based microdevices serving as carriers for poorly soluble drugs, hereby called microcontainers (1).
    Microcontainers have a cylindrical geometry and provide a unidirectional release due to their design meanwhile protecting the drug formulation from the low gastric pH and the enzymatic degradation. Here, we present the preparation of microcontainers with enteric coating (2) efficiently loaded with drug and able to target the intestine as a multi-particulate system.
    Original languageEnglish
    Publication date2016
    Number of pages2
    Publication statusPublished - 2016
    Event11th Central European Symposium on Pharmaceutical Technology - University of Belgrade, Belgrade, Serbia
    Duration: 22 Sept 201624 Sept 2016
    Conference number: 11
    http://sphu.org/en/the-11th-central-european-symposium-on-pharmaceutical-technology.html

    Conference

    Conference11th Central European Symposium on Pharmaceutical Technology
    Number11
    LocationUniversity of Belgrade
    Country/TerritorySerbia
    CityBelgrade
    Period22/09/201624/09/2016
    Internet address

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