Microcontainers for Intestinal Drug Delivery

Fabio Tentor, Chiara Mazzoni, Stephan Sylvest Keller, Paolo Marizza, Anja Boisen

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Abstract

Among all the drug administration routes, the oral one is the most preferred by the patients being less invasive, faster and easier.
Oral drug delivery systems designed to target the intestine are produced by powder technology and capsule formulations. Those systems including micro- and nano-particulate systems (i.e. vesicles, polymer nanoparticles, dendrimers etc.) suffer the non-unidirectional release of the drug to the epithelium of the intestine, which entails an inevitable loss in the lumen and, therefore, the reduction of the drug delivered to the intestinal epithelium. A new promising approach focuses on reservoir based microdevices serving as carriers for poorly soluble drugs, hereby called microcontainers (1).
Microcontainers have a cylindrical geometry and provide a unidirectional release due to their design meanwhile protecting the drug formulation from the low gastric pH and the enzymatic degradation. Here, we present the preparation of microcontainers with enteric coating (2) efficiently loaded with drug and able to target the intestine as a multi-particulate system.
Original languageEnglish
Publication date2016
Number of pages2
Publication statusPublished - 2016
Event11th Central European Symposium on Pharmaceutical Technology - University of Belgrade, Belgrade, Serbia
Duration: 22 Sep 201624 Sep 2016
Conference number: 11

Conference

Conference11th Central European Symposium on Pharmaceutical Technology
Number11
LocationUniversity of Belgrade
CountrySerbia
CityBelgrade
Period22/09/201624/09/2016

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