Microcontainers for improved treatment of Pseudomonas aeruginosa biofilm infections

Stine Egebro Hansen, Line Hagner Nielsen, Janus Anders Juul Haagensen, Helle Krogh Johansen, Søren Molin, Anja Boisen

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review


Lung infections with Pseudomonas aeruginosa are difficult to eradicate as it forms biofilm that protects the bacteria from the host immune response and hinders antibiotics to reach the site of infection [1]. Inhaled powdered antibiotics have the limitation that they distribute in all areas of the lungs and a certain degree of dilution takes place hence, a more targeted delivery is needed. Micrometer sized polymeric containers (microcontainers) have been developed for oral delivery of therapeutics and studies have shown that the microcontainers are engulfed by the intestinal mucus [2]. We hypothesize that the microcontainers can be utilized in the treatment of biofilms as they are suggested to penetrate the biofilm and release the antibiotics in a more controlled manner at the target site compared to conventional inhaled antibiotics. Therefore, the purpose of this work was to load microcontainers with antibiotic, to coat with three different coatings and lastly test the microcontainers on P. aeruginosa grown planktonically or as biofilm.
Original languageEnglish
Publication date2019
Number of pages2
Publication statusPublished - 2019
Event2019 Controlled Release Society Annual Meeting & Exposition - Palacio de Congresos de València, Valencia, Spain
Duration: 21 Jul 201924 Jul 2019


Conference2019 Controlled Release Society Annual Meeting & Exposition
LocationPalacio de Congresos de València


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