Microchip Coulter particle counter

Ulrik Darling Larsen, Gert Blankenstein, J. Branebjerg

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    Abstract

    This paper presents a micro device employing the Coulter principle for counting and sizing of living cells and particles in liquid suspension. The microchip Coulter particle counter (μCPC) has been employed in a planar silicon structure covered with glass, which enables detailed observation during operation. By sheathing of a nonconductive liquid on either side of an electrolyte, it is possible to optimize the sensitivity to a specific cell-size. A method for measuring the relative flow-rates between liquid phases with different conductivity is presented. The method utilizes the laminar flow and short contact time of liquids in microchannels. As a result, the width of the liquids can be controlled without knowing the actual flow rates. The μCPC has been fabricated by standard microfabrication techniques, including RIE, wet silicon etching, metalization and anodic bonding
    Original languageEnglish
    Title of host publicationSolid State Sensors and Actuators, 1997. TRANSDUCERS '97 Chicago., 1997 International Conference on
    Volume2
    PublisherIEEE
    Publication date1997
    Pages1319-1322
    ISBN (Print)0-7803-3829-4
    DOIs
    Publication statusPublished - 1997
    EventInternational Conference on Solid-state Sensors and Actuators (Transducers 1997) - Chicago,IL, United States
    Duration: 16 Jun 199719 Jun 1997

    Conference

    ConferenceInternational Conference on Solid-state Sensors and Actuators (Transducers 1997)
    Country/TerritoryUnited States
    CityChicago,IL
    Period16/06/199719/06/1997

    Bibliographical note

    Copyright: 1997 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

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