Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus

Louise Kristine Vigsnæs, Pieter van den Abbeele, Karolina Sulek, Henrik Lauritz Frandsen, Casper Steenholdt, Jørn Brynskov, Joan Vermeiren, Tom van de Wiele, Tine Rask Licht

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We compared fecal microbial communities derived either from Ulcerative Colitis (UC) patients in remission (n = 4) or in relapse (n = 4), or from healthy subjects (n = 4). These communities were used for inoculation of a dynamic in vitro gut model, which contained integrated mucin-covered microcosms. We found that the microbiota of the 'mucus' largely differed from that of the 'lumen'. This was partly due to decreased mucus-associated populations of lactic acid producing bacterial populations (LAB), as LAB originating from UC patients had a significantly decreased capacity to colonize the mucin-covered microcosms as compared to those originating from healthy subjects. We found significant differences between the metabolomes of UC patients in relapse and remission, respectively, while the metabolome of patients in remission resembled that of healthy subjects. These novel findings constitute an important contribution to the understanding of the complex etiology of UC.
Original languageEnglish
Article number1110
JournalScientific Reports
Volume3
Number of pages10
ISSN2045-2322
DOIs
Publication statusPublished - 2013

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