Microbial regulatory and metabolic networks

Byung-Kwan Cho, Pep Charusanti, Markus Herrgard, Bernhard ∅. Palsson

Research output: Contribution to journalJournal articleResearchpeer-review


Reconstruction of transcriptional regulatory and metabolic networks is the foundation of large-scale microbial systems and synthetic biology. An enormous amount of information including the annotated genomic sequences and the genomic locations of DNA-binding regulatory proteins can be used to define metabolic and regulatory networks in cells. In particular, advances in experimental methods to map regulatory networks in microbial cells have allowed reliable data-driven reconstruction of these networks. Recent work on metabolic engineering and experimental evolution of microbes highlights the key role of global regulatory networks in controlling specific metabolic processes and the need to consider the integrated function of multiple types of networks for both scientific and engineering purposes.
Original languageEnglish
JournalCurrent Opinion in Biotechnology
Issue number4
Pages (from-to)360-364
Publication statusPublished - 2007
Externally publishedYes


Dive into the research topics of 'Microbial regulatory and metabolic networks'. Together they form a unique fingerprint.

Cite this