Microbial profiling identifies potential key drivers in gastric cancer patients

Yonghong Li, Jia Wang, Mengge Wang, Yongshun Gao, Cheng Yun Jin, Xiaojing Shi*, Boyang Ji, Yongjun Wei, Hongmin Liu

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Gastric cancer (GC) is the fifth most commonly diagnosed cancer and the third leading cause of cancer-related death in the world. Microbiota is believed to be associated with GC. Growing evidences showed Helicobacter pylori played a key role in GC development. However, little was known about the microbiota in gastric juices and tissues in GC patients, and thus it was difficult to understand other potential microbial causation for GC. Here, we collected the gastric juice and surgically removed gastric tissues from GC patients to give insight into GC microbiota. Most microbes identified in the gastric samples were opportunistic pathogens or resident flora of the human microbiota. Further network analyses identified five opportunistic pathogens as keystone species. H. pylori is the direct cause of GC, but other opportunistic microbes might also function in GC development. The microbiota in the gastric juice and gastric tissue of the GC patients were complex, and some dominant opportunistic pathogens contributed to the GC development. This study introduces microbiota in gastric juice, gastric normal tissue and gastric cancer tissue of GC patients, and highlights the potential keystone microbes functioned during GC development.

Original languageEnglish
JournalBiotechnology & Biotechnological Equipment
Issue number1
Pages (from-to)496-503
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 3201101906), Higher Education Key Scientific Research Projects of Henan Province (No. 19A350012), Clinical Laborotories, Shenyou Bio., Institute of Henan modern biotechnology Co. Ltd (No. HMB0066), and Zhengzhou University Startup Foundation (No. 32210876). We thank DeepBiome Co., Ltd. for bioinformatic assistance. We thank Zhiyi Xu at Charit? Universit?tsmedizin Berlin for polishing English writing of this manuscript.

Publisher Copyright:
© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.


  • Gastric cancer
  • Helicobacter pylori
  • Microbiota
  • Network analysis
  • Opportunistic pathogens


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