Microbial production of the flavonoids garbanzol, resokaempferol and fisetin

Steen Gustav Stahlhut; Solvej Siedler; Ana Rute Neves; JEROME MAURY,; Jochen Förster; Paula Gaspar; Irina Borodina; Edith Angelica Rodriguez Prado; Tomas Strucko

Microbial production of the flavonoids garbanzol, resokaempferol and fisetin

Steen Gustav Stahlhut (Inventor), Solvej Siedler (Inventor), Ana Rute Neves (Inventor), JEROME MAURY, (Inventor), Jochen Förster (Inventor), Paula Gaspar (Inventor), Irina Borodina (Inventor), Edith Angelica Rodriguez Prado (Inventor), Tomas Strucko (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell engineered to express a metabolic pathway for garbanzol, resokaempferol and/or fisetin biosynthesis. The invention further provides a method for producing garbanzol, resokaempferol and/or fisetin employing the genetically modified micro-organism of the invention. The genetically modified micro- organism may be used to convert a number of substrates and/or co-substrates into fisetin via a fisetin biosynthetic pathway.

Original language	English
IPC	C07D 311/ 30 A I
Patent number	WO2016071505
Filing date	12/05/2016
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	11/06/2015
Priority number	EP20150171638
Publication status	Published - 12 May 2016

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title = "Microbial production of the flavonoids garbanzol, resokaempferol and fisetin",

abstract = "The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell engineered to express a metabolic pathway for garbanzol, resokaempferol and/or fisetin biosynthesis. The invention further provides a method for producing garbanzol, resokaempferol and/or fisetin employing the genetically modified micro-organism of the invention. The genetically modified micro- organism may be used to convert a number of substrates and/or co-substrates into fisetin via a fisetin biosynthetic pathway.",

author = "Stahlhut, {Steen Gustav} and Solvej Siedler and Neves, {Ana Rute} and JEROME MAURY, and Jochen F{\"o}rster and Paula Gaspar and Irina Borodina and {Rodriguez Prado}, {Edith Angelica} and Tomas Strucko",

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TY - PAT

T1 - Microbial production of the flavonoids garbanzol, resokaempferol and fisetin

AU - Stahlhut, Steen Gustav

AU - Siedler, Solvej

AU - Neves, Ana Rute

AU - MAURY,, JEROME

AU - Förster, Jochen

AU - Gaspar, Paula

AU - Borodina, Irina

AU - Rodriguez Prado, Edith Angelica

AU - Strucko, Tomas

PY - 2016/5/12

Y1 - 2016/5/12

N2 - The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell engineered to express a metabolic pathway for garbanzol, resokaempferol and/or fisetin biosynthesis. The invention further provides a method for producing garbanzol, resokaempferol and/or fisetin employing the genetically modified micro-organism of the invention. The genetically modified micro- organism may be used to convert a number of substrates and/or co-substrates into fisetin via a fisetin biosynthetic pathway.

AB - The invention provides a genetically modified micro-organism comprising one or more transgene for the production of one or more of the flavonoids garbanzol, resokaempferol and fisetin. The micro-organism may be a bacterial or yeast cell engineered to express a metabolic pathway for garbanzol, resokaempferol and/or fisetin biosynthesis. The invention further provides a method for producing garbanzol, resokaempferol and/or fisetin employing the genetically modified micro-organism of the invention. The genetically modified micro- organism may be used to convert a number of substrates and/or co-substrates into fisetin via a fisetin biosynthetic pathway.

M3 - Patent

M1 - WO2016071505

Y2 - 2016/05/12

ER -

Microbial production of the flavonoids garbanzol, resokaempferol and fisetin

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