Microbial production of 3-hydroxypropionic acid

Niels Bjerg Jensen (Inventor), Irina Borodina (Inventor), Yun Chen (Inventor), Jerome Maury (Inventor), Kanchana Rueksomtawin Kildegaard (Inventor), Jochen Förster (Inventor), Jens Nielsen (Inventor)

Research output: Patent

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Abstract

A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

Original languageEnglish
IPCC12N9/00
Patent numberWO2014198831
Filing date18/12/2014
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date14/06/2013
Priority numberEP20130172149
Publication statusPublished - 2014

Bibliographical note

Also published as: US2016138056 (A1); EP3008178 (A1)

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