Microbial production of 3-hydroxypropionic acid

Niels Bjerg Jensen; Irina Borodina; Yun Chen; Jerome Maury; Kanchana Rueksomtawin Kildegaard; Jochen Förster; Jens Nielsen

Microbial production of 3-hydroxypropionic acid

Niels Bjerg Jensen (Inventor), Irina Borodina (Inventor), Yun Chen (Inventor), Jerome Maury (Inventor), Kanchana Rueksomtawin Kildegaard (Inventor), Jochen Förster (Inventor), Jens Nielsen (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

Original language	English
IPC	C12N9/00
Patent number	WO2014198831
Filing date	18/12/2014
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	14/06/2013
Priority number	EP20130172149
Publication status	Published - 2014

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Also published as: US2016138056 (A1); EP3008178 (A1)

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title = "Microbial production of 3-hydroxypropionic acid",

abstract = "A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.",

author = "Jensen, {Niels Bjerg} and Irina Borodina and Yun Chen and Jerome Maury and Kildegaard, {Kanchana Rueksomtawin} and Jochen F{\"o}rster and Jens Nielsen",

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year = "2014",

language = "English",

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TY - PAT

T1 - Microbial production of 3-hydroxypropionic acid

AU - Jensen, Niels Bjerg

AU - Borodina, Irina

AU - Chen, Yun

AU - Maury, Jerome

AU - Kildegaard, Kanchana Rueksomtawin

AU - Förster, Jochen

AU - Nielsen, Jens

N1 - Also published as: US2016138056 (A1); EP3008178 (A1)

PY - 2014

Y1 - 2014

N2 - A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

AB - A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

M3 - Patent

M1 - WO2014198831

Y2 - 2014/12/18

ER -

Microbial production of 3-hydroxypropionic acid

Abstract

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