Microbial production of 3-hydroxypropionic acid

Niels Bjerg Jensen (Inventor), Irina Borodina (Inventor), Yun Chen (Inventor), Jerome Maury (Inventor), Kanchana Rueksomtawin Kildegaard (Inventor), Jochen Förster (Inventor), Jens Nielsen (Inventor)

Research output: Patent

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Abstract

A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

Original languageEnglish
IPCC12N9/00
Patent numberWO2014198831
Filing date18/12/2014
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date14/06/2013
Priority numberEP20130172149
Publication statusPublished - 2014

Bibliographical note

Also published as: US2016138056 (A1); EP3008178 (A1)

Cite this

Jensen, N. B., Borodina, I., Chen, Y., Maury, J., Kildegaard, K. R., Förster, J., & Nielsen, J. (2014). IPC No. C12N9/00. Microbial production of 3-hydroxypropionic acid. (Patent No. WO2014198831).
Jensen, Niels Bjerg (Inventor) ; Borodina, Irina (Inventor) ; Chen, Yun (Inventor) ; Maury, Jerome (Inventor) ; Kildegaard, Kanchana Rueksomtawin (Inventor) ; Förster, Jochen (Inventor) ; Nielsen, Jens (Inventor). / Microbial production of 3-hydroxypropionic acid. IPC No.: C12N9/00. Patent No.: WO2014198831. Dec 18, 2014.
@misc{80586d8786604a32aff51bdaba5252ae,
title = "Microbial production of 3-hydroxypropionic acid",
abstract = "A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.",
author = "Jensen, {Niels Bjerg} and Irina Borodina and Yun Chen and Jerome Maury and Kildegaard, {Kanchana Rueksomtawin} and Jochen F{\"o}rster and Jens Nielsen",
note = "Also published as: US2016138056 (A1); EP3008178 (A1) ; WO2014198831; C12N9/00",
year = "2014",
language = "English",
type = "Patent",

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Jensen, NB, Borodina, I, Chen, Y, Maury, J, Kildegaard, KR, Förster, J & Nielsen, J Dec. 18 2014, Microbial production of 3-hydroxypropionic acid, Patent No. WO2014198831, IPC No. C12N9/00.

Microbial production of 3-hydroxypropionic acid. / Jensen, Niels Bjerg (Inventor); Borodina, Irina (Inventor); Chen, Yun (Inventor); Maury, Jerome (Inventor); Kildegaard, Kanchana Rueksomtawin (Inventor); Förster, Jochen (Inventor); Nielsen, Jens (Inventor).

IPC No.: C12N9/00. Patent No.: WO2014198831. Dec 18, 2014.

Research output: Patent

TY - PAT

T1 - Microbial production of 3-hydroxypropionic acid

AU - Jensen, Niels Bjerg

AU - Borodina, Irina

AU - Chen, Yun

AU - Maury, Jerome

AU - Kildegaard, Kanchana Rueksomtawin

AU - Förster, Jochen

AU - Nielsen, Jens

N1 - Also published as: US2016138056 (A1); EP3008178 (A1)

PY - 2014

Y1 - 2014

N2 - A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

AB - A yeast cell havinga reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.

M3 - Patent

M1 - WO2014198831

Y2 - 2014/12/18

ER -

Jensen NB, Borodina I, Chen Y, Maury J, Kildegaard KR, Förster J et al, inventors. Microbial production of 3-hydroxypropionic acid. C12N9/00. 2014.