Microbial platform for production of aromatic compounds

Research output: Contribution to conferencePosterResearchpeer-review

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Abstract

Polyketides form the basic building blocks of numerous natural products, which are in use in pharmaceuticals, food additives and other fine chemicals. Many of these polyketides possess very specific cyclic and aromatic conformations. The programmable platform we aim to create will be able to efficiently and directly produce a vast array of polyketide derived compounds. The platform will be integrated in a well known heterologous host to improve the predictability and engineering options of the platform.
The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.
Original languageEnglish
Publication date2017
Number of pages1
Publication statusPublished - 2017

Cite this

@conference{6bdbea7eaf1342debaef7266ffe78f36,
title = "Microbial platform for production of aromatic compounds",
abstract = "Polyketides form the basic building blocks of numerous natural products, which are in use in pharmaceuticals, food additives and other fine chemicals. Many of these polyketides possess very specific cyclic and aromatic conformations. The programmable platform we aim to create will be able to efficiently and directly produce a vast array of polyketide derived compounds. The platform will be integrated in a well known heterologous host to improve the predictability and engineering options of the platform.The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.",
author = "Skovbjerg, {Christine Alexandra Egaa} and Olsen, {Kresten Jon Kromphardt} and Larsen, {Thomas Ostenfeld} and Frandsen, {Rasmus John Normand}",
year = "2017",
language = "English",

}

Microbial platform for production of aromatic compounds. / Skovbjerg, Christine Alexandra Egaa; Olsen, Kresten Jon Kromphardt; Larsen, Thomas Ostenfeld; Frandsen, Rasmus John Normand.

2017.

Research output: Contribution to conferencePosterResearchpeer-review

TY - CONF

T1 - Microbial platform for production of aromatic compounds

AU - Skovbjerg, Christine Alexandra Egaa

AU - Olsen, Kresten Jon Kromphardt

AU - Larsen, Thomas Ostenfeld

AU - Frandsen, Rasmus John Normand

PY - 2017

Y1 - 2017

N2 - Polyketides form the basic building blocks of numerous natural products, which are in use in pharmaceuticals, food additives and other fine chemicals. Many of these polyketides possess very specific cyclic and aromatic conformations. The programmable platform we aim to create will be able to efficiently and directly produce a vast array of polyketide derived compounds. The platform will be integrated in a well known heterologous host to improve the predictability and engineering options of the platform.The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.

AB - Polyketides form the basic building blocks of numerous natural products, which are in use in pharmaceuticals, food additives and other fine chemicals. Many of these polyketides possess very specific cyclic and aromatic conformations. The programmable platform we aim to create will be able to efficiently and directly produce a vast array of polyketide derived compounds. The platform will be integrated in a well known heterologous host to improve the predictability and engineering options of the platform.The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.

M3 - Poster

ER -