Abstract
Polyketides form the basic building blocks of numerous natural products, which are in use in pharmaceuticals, food additives and other fine chemicals. Many of these polyketides possess very specific cyclic and aromatic conformations. The programmable platform we aim to create will be able to efficiently and directly produce a vast array of polyketide derived compounds. The platform will be integrated in a well known heterologous host to improve the predictability and engineering options of the platform.
The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.
The basic platform will allow production of polyketides of different lengths and folding patterns. The biosynthesis of the polyketides is divided into different steps and by swapping either domains between enzymes or whole enzymes between pathways the length of the polyketides or the individual folding pattern can be directed towards a desired product. Further development of the platform will be combinations of more enzymes to enlarge the possible chemical diversity of the platform.
| Original language | English |
|---|---|
| Publication date | 2017 |
| Number of pages | 1 |
| Publication status | Published - 2017 |