Microbial ecology and adaptation in cystic fibrosis airways

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Chronic infections in the respiratory tracts of cystic fibrosis (CF) patients are important to investigate, both from medical and from fundamental ecological points of view. Cystic fibrosis respiratory tracts can be described as natural environments harbouring persisting microbial communities with Pseudomonas aeruginosa as a dominant pathogen. Various factors contribute to the complexity of this ecosystem, including community composition, dynamics and interactions, as well as heterogeneous distribution and fluctuation of components of the immune system, antibiotics and nutrients. All these elements constitute the selective forces that drive the evolution of the microbes after they migrate from the outer environment to human airways. Pseudomonas aeruginosa adapts to the new environment through genetic changes and exhibits a special lifestyle in chronic CF airways. Understanding the persistent colonization of microbial pathogens in CF patients in the context of ecology and evolution will expand our knowledge of the pathogenesis of chronic infections and improve therapeutic strategies.
    Original languageEnglish
    JournalEnvironmental Microbiology
    Volume13
    Issue number7
    Pages (from-to)1682-1689
    ISSN1462-2912
    DOIs
    Publication statusPublished - 2011

    Cite this

    @article{ef572f6c45d444a6b11e1928b221f940,
    title = "Microbial ecology and adaptation in cystic fibrosis airways",
    abstract = "Chronic infections in the respiratory tracts of cystic fibrosis (CF) patients are important to investigate, both from medical and from fundamental ecological points of view. Cystic fibrosis respiratory tracts can be described as natural environments harbouring persisting microbial communities with Pseudomonas aeruginosa as a dominant pathogen. Various factors contribute to the complexity of this ecosystem, including community composition, dynamics and interactions, as well as heterogeneous distribution and fluctuation of components of the immune system, antibiotics and nutrients. All these elements constitute the selective forces that drive the evolution of the microbes after they migrate from the outer environment to human airways. Pseudomonas aeruginosa adapts to the new environment through genetic changes and exhibits a special lifestyle in chronic CF airways. Understanding the persistent colonization of microbial pathogens in CF patients in the context of ecology and evolution will expand our knowledge of the pathogenesis of chronic infections and improve therapeutic strategies.",
    author = "Lei Yang and Lars Jelsbak and S{\o}ren Molin",
    year = "2011",
    doi = "10.1111/j.1462-2920.2011.02459.x",
    language = "English",
    volume = "13",
    pages = "1682--1689",
    journal = "Environmental Microbiology",
    issn = "1462-2912",
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    }

    Microbial ecology and adaptation in cystic fibrosis airways. / Yang, Lei; Jelsbak, Lars; Molin, Søren.

    In: Environmental Microbiology, Vol. 13, No. 7, 2011, p. 1682-1689.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Microbial ecology and adaptation in cystic fibrosis airways

    AU - Yang, Lei

    AU - Jelsbak, Lars

    AU - Molin, Søren

    PY - 2011

    Y1 - 2011

    N2 - Chronic infections in the respiratory tracts of cystic fibrosis (CF) patients are important to investigate, both from medical and from fundamental ecological points of view. Cystic fibrosis respiratory tracts can be described as natural environments harbouring persisting microbial communities with Pseudomonas aeruginosa as a dominant pathogen. Various factors contribute to the complexity of this ecosystem, including community composition, dynamics and interactions, as well as heterogeneous distribution and fluctuation of components of the immune system, antibiotics and nutrients. All these elements constitute the selective forces that drive the evolution of the microbes after they migrate from the outer environment to human airways. Pseudomonas aeruginosa adapts to the new environment through genetic changes and exhibits a special lifestyle in chronic CF airways. Understanding the persistent colonization of microbial pathogens in CF patients in the context of ecology and evolution will expand our knowledge of the pathogenesis of chronic infections and improve therapeutic strategies.

    AB - Chronic infections in the respiratory tracts of cystic fibrosis (CF) patients are important to investigate, both from medical and from fundamental ecological points of view. Cystic fibrosis respiratory tracts can be described as natural environments harbouring persisting microbial communities with Pseudomonas aeruginosa as a dominant pathogen. Various factors contribute to the complexity of this ecosystem, including community composition, dynamics and interactions, as well as heterogeneous distribution and fluctuation of components of the immune system, antibiotics and nutrients. All these elements constitute the selective forces that drive the evolution of the microbes after they migrate from the outer environment to human airways. Pseudomonas aeruginosa adapts to the new environment through genetic changes and exhibits a special lifestyle in chronic CF airways. Understanding the persistent colonization of microbial pathogens in CF patients in the context of ecology and evolution will expand our knowledge of the pathogenesis of chronic infections and improve therapeutic strategies.

    U2 - 10.1111/j.1462-2920.2011.02459.x

    DO - 10.1111/j.1462-2920.2011.02459.x

    M3 - Journal article

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    EP - 1689

    JO - Environmental Microbiology

    JF - Environmental Microbiology

    SN - 1462-2912

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