Microbial cells and methods for production of hernandulcin

Irina Borodina (Inventor), Jonathan Asmund Arnesen (Inventor), Jane Dannow Dyekjær (Inventor)

Research output: Patent

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The present invention relates to microbial production of the sweet non-calorigenic sesquiterpenoid hernandulcin. Disclosed herein are yeast cells capable of producing hernandulcin and optionally hernandulcin derivatives, said yeast cells expressing at least one (+)-epi-alpha-bisabolol synthase, at least one cytochrome P450 enzyme (CYP) and at least one cytochrome P450 reductase, preferably said CYP the Nicotiana tabacum CYP 5-epi-aristolocene dihydroxylase (NtEAH) or the Datura stramonium cytochrome P450 enzyme DsEAH.

Original languageEnglish
IPCC12P 5/ 00 A I
Patent numberWO2023242403
Filing date16/06/2022
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date16/06/2022
Priority numberEP20220179430
Publication statusPublished - 21 Dec 2023


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