Micro-organism for the production of stereo-specific s, s-2,3-butanediol

Christian Solem (Inventor), Peter Ruhdal Jensen (Inventor), Jun Chen (Inventor), Jianming Liu (Inventor)

Research output: Patent

107 Downloads (Pure)

Abstract

The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe3+/Fe2+). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butanediol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.

Original languageEnglish
IPCC12R 1/ 225 A N
Patent numberWO2016097268
Filing date23/06/2016
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date27/10/2015
Priority numberEP20150191703
Publication statusPublished - 23 Jun 2016

Cite this

Solem, C., Jensen, P. R., Chen, J., & Liu, J. (2016). IPC No. C12R 1/ 225 A N. Micro-organism for the production of stereo-specific s, s-2,3-butanediol. (Patent No. WO2016097268).
@misc{36c2045b904d4ad9828c7047243d05fa,
title = "Micro-organism for the production of stereo-specific s, s-2,3-butanediol",
abstract = "The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe3+/Fe2+). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butanediol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.",
author = "Christian Solem and Jensen, {Peter Ruhdal} and Jun Chen and Jianming Liu",
year = "2016",
month = "6",
day = "23",
language = "English",
type = "Patent",
note = "WO2016097268; C12R 1/ 225 A N",

}

Solem, C, Jensen, PR, Chen, J & Liu, J Jun. 23 2016, Micro-organism for the production of stereo-specific s, s-2,3-butanediol, Patent No. WO2016097268, IPC No. C12R 1/ 225 A N.

Micro-organism for the production of stereo-specific s, s-2,3-butanediol. / Solem, Christian (Inventor); Jensen, Peter Ruhdal (Inventor); Chen, Jun (Inventor); Liu, Jianming (Inventor).

IPC No.: C12R 1/ 225 A N. Patent No.: WO2016097268. Jun 23, 2016.

Research output: Patent

TY - PAT

T1 - Micro-organism for the production of stereo-specific s, s-2,3-butanediol

AU - Solem, Christian

AU - Jensen, Peter Ruhdal

AU - Chen, Jun

AU - Liu, Jianming

PY - 2016/6/23

Y1 - 2016/6/23

N2 - The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe3+/Fe2+). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butanediol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.

AB - The invention relates to a genetically modified lactic acid bacterium capable of producing (S,S)-2,3-butanediol stereo specifically from glucose under aerobic conditions. Additionally the invention relates to a method for producing (S,S)-2,3-butanediol and L-acetoin using the genetically modified lactic acid bacterium, under aerobic conditions in the presence of a source of iron-containing porphyrin or a source of metal ions (Fe3+/Fe2+). The lactic acid bacterium is genetically modified to express heterologous genes encoding enzymes catalysing the stereo-specific synthesis of (S,S)-2,3-butanediol; and additionally a number of genes are deleted in order to maximise the production of (S,S)-2,3-butanediol as compared to other products of oxidative fermentation.

M3 - Patent

M1 - WO2016097268

Y2 - 2016/06/23

ER -