Abstract
The
optics
and
mechanics
from
a
DVD
player
can
be
used
to
realize
compact
and
sensitive
sensor
systems.
By
rotating
a
disc
with
integrated
microfluidic
channels
it
is
possible
to
manipulate
liquid
samples
such
as
blood
–
performing
crucial
operations
like
separation,
valving
and
mixing.
We
integrate
sensors
such
as
cantilevers,
nanoparticles
and
resonating
strings
with
centrifugal
microfluidics.
The
sensors
are
read
out
by
a
DVD
pick-‐up
head
which
can
perform
transmission/absorption
measurements
and
which
can
detect
nm
deflections.
Also,
electrodes
are
integrated
on
a
disc
platform,
facilitating
electrochemical
measurements.
In
cantilever-‐based
sensing,
micrometer
sized
cantilevers
are
functionalized
on
one
side
with
probe
molecules.
As
target
analytes
bind
to
the
probe
molecules
the
cantilever
deflects
due
to
changes
in
surface
stress.
This
deflection
is
typically
in
the
nm
range
and
normally
only
a
few
cantilevers
can
be
read-‐out
simultaneously.
Using
a
rotating
disc
system
hundreds
of
cantilevers
can
be
read-‐out
in
one
second.
We
will
demonstrate
how
this
approach
can
be
used
for
detection
of
biomarkers.
Hollow
cantilevers
will
be
briefly
discussed
as
a
new
way
of
performing
IR
spectroscopy
on
picoliter
amount
of
sample.
Vibrating
micrometer
sized
strings
can
be
used
for
efficient
and
sensitive
mass
detection
and
for
chemical
analysis
of
single
nanoparticles.
We
will
show
examples
from
drug
characterization
and
illustrate
how
the
strings
can
be
read-‐out
using
blu-‐ray
optics.
Finally,
we
will
show
how
agglutination
based
assays
can
be
handled
and
read-‐out
using
the
disc
platform
–
here
targeting
biomarkers
for
rapid
diagnostics
and
prognostics.
Micrometer
sized
containers
can
be
used
for
oral
drug
delivery.
The
hypothesis
is
that
oral
drug
delivery
can
be
improved
significantly
by
utilizing
micrometer
sized
containers
loaded
with
drug(s)
and
sealed
by
intelligent
lids
that
open
at
specific
locations
in
the
body.
The
containers
will,
among
other
features,
protect
active
pharmaceutical
ingredients
(APIs)
during
the
passage
through
the
stomach
and
facilitate
adhesion
to
the
wall
of
the
intestine
for
controlled
and
unidirectional
release,
followed
by
absorption
through
the
intestinal
wall.
We
will
show
our
recent
findings
and
results.
Original language | English |
---|---|
Title of host publication | Abstract Book - DTU Sustain Conference 2014 |
Number of pages | 1 |
Place of Publication | Kgs. Lyngby |
Publisher | Technical University of Denmark |
Publication date | 2014 |
Publication status | Published - 2014 |
Event | DTU Sustain Conference 2014 - Technical University of Denmark, Lyngby, Denmark Duration: 17 Dec 2014 → 17 Dec 2014 http://www.sustain.dtu.dk/ |
Conference
Conference | DTU Sustain Conference 2014 |
---|---|
Location | Technical University of Denmark |
Country/Territory | Denmark |
City | Lyngby |
Period | 17/12/2014 → 17/12/2014 |
Internet address |