Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011

J. Larsen, A. Petersen, M. Sørum, M. Stegger, L. van Alphen, P. Valentiner-Branth, L. K. Knudsen, Lars Stehr Larsen, B. Feingold, L. B. Price, P. S. Andersen, A. R. Larsen, R. L. Skov

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Abstract

Livestock constitutes a potential reservoir of meticillin-resistant Staphylococcus aureus isolates belonging to a recently derived lineage within clonal complex 398 (MRSA CC398-IIa). Since its discovery in the early 2000s, this lineage has become a major cause of human disease in Europe, posing a serious public health challenge in countries with intensive livestock production. To retrace the history of human colonisation and infection with MRSA CC398-IIa in Denmark, we conducted a nationwide, retrospective study of MRSA isolates collected from 1999 to 2011. Among 7,429 MRSA isolates screened, we identified 416 MRSA CC398-IIa isolates. Of these, 148 were from people with infections, including 51 from patients reporting no livestock exposure. The first cases of MRSA CC398-IIa infection in Denmark occurred in 2004. Subsequently, the incidence of MRSA CC398-IIa infection showed a linear annual increase of 66% from 2004 to 2011 (from 0.09 to 1.1 per 100,000 person-years). There were clear temporal and spatial relationships between MRSA CC398-IIa-infected patients with and without livestock exposure. These findings suggest substantial dissemination of MRSA CC398-IIa from livestock or livestock workers into the Danish community and underscore the need for strategies to control its spread both on and off the farm.
Original languageEnglish
JournalEurosurveillance (Online Edition)
Volume20
Issue number37
Pages (from-to)5-13
Number of pages9
ISSN1025-496X
DOIs
Publication statusPublished - 2015

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Larsen, J., Petersen, A., Sørum, M., Stegger, M., van Alphen, L., Valentiner-Branth, P., Knudsen, L. K., Larsen, L. S., Feingold, B., Price, L. B., Andersen, P. S., Larsen, A. R., & Skov, R. L. (2015). Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011. Eurosurveillance (Online Edition), 20(37), 5-13. https://doi.org/10.2807/1560-7917.es.2015.20.37.30021