Methylenedioxy- and methoxyflavones from Melicope coodeana syn. Euodia simplex

Henrik Toft Simonsen, M. D. Larsen, M. W. Nielsen, A. Adsersen, C. E. Olsen, D. Strasberg, U. W. Smitt, J. W. Jaroszewsk

Research output: Contribution to journalJournal articleResearchpeer-review


Three new natural products, 3,8-dimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone, 3,6,8-trimethoxy-5,7-dihydroxy-3',4'-methylenedioxyflavone and 3,6,8,3',4'-pentamethoxy-5,7-dihydroxyflavone were isolated from Melicope coodeana syn. Euodia simplex (Rutaceae) along with 3,6,3-trimethoxy-5,7,4'-trihydroxyflavone and 3,3'-dimethoxy-5,7,4'-trihydroxyflavone. The structural assignments are based on 1H and 13C NMR data, including discussion of the chemical shifts of C-2 in 3,5-dihydroxy- and 3-methoxy-5-hydroxyflavones. The presence of highly methoxylated and methylenedioxyflavones is characteristic of the genus Melicope, and the present findings support the recent transfer of Euodia simplex to Melicope.
Original languageEnglish
Issue number8
Pages (from-to)817-820
Number of pages4
Publication statusPublished - 2002
Externally publishedYes


  • Rutaceae
  • Euodia simplex
  • Melicope coodeana
  • Methylenedioxyflavones
  • Methoxyflavones
  • C-13 NMR
  • Chemotaxonomy
  • Reunion Island


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