Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials

Oskar Axelsson (Inventor), Haukur Johannesson (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor), Ib Laursen (Inventor)

Research output: Patent

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Abstract

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising: (i) nuclear spin polarising a solid MR imaging agent (i.e. a material containing in its molecular structure a non-zero nuclear spin nucleus) by (a) spin refrigeration, or by, (b) irradiating with circularly polarised light; (ii) administering the nuclear spin polarised MR imaging agent to said sample, preferably after dissolution in a physiologically tolerable solvent and also preferably after separation form some or all of the paramagnetic species or chromophores; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in selected nuclei therein, e.g. the spin polarised nuclei of the MR imaging agent; (iv) detecting magnetic resonance signals form said sample; and (v) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (e.g. pH, pO2, pCO2, temperature or ionic concentrations) or metabolic data from said detected signals.

Original languageEnglish
IPCG01R 33/ 28 A I
Patent numberGB2364785
Filing date06/02/2002
CountryUnited Kingdom
Priority date17/05/2000
Priority numberWO2000GB01888
Publication statusPublished - 6 Feb 2002
Externally publishedYes

Cite this

Axelsson, Oskar (Inventor) ; Johannesson, Haukur (Inventor) ; Ardenkjær-Larsen, Jan Henrik (Inventor) ; Laursen, Ib (Inventor). / Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials. IPC No.: G01R 33/ 28 A I. Patent No.: GB2364785. Feb 06, 2002.
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author = "Oskar Axelsson and Haukur Johannesson and Ardenkj{\ae}r-Larsen, {Jan Henrik} and Ib Laursen",
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Axelsson, O, Johannesson, H, Ardenkjær-Larsen, JH & Laursen, I Feb. 06 2002, Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials, Patent No. GB2364785, IPC No. G01R 33/ 28 A I.

Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials. / Axelsson, Oskar (Inventor); Johannesson, Haukur (Inventor); Ardenkjær-Larsen, Jan Henrik (Inventor); Laursen, Ib (Inventor).

IPC No.: G01R 33/ 28 A I. Patent No.: GB2364785. Feb 06, 2002.

Research output: Patent

TY - PAT

T1 - Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials

AU - Axelsson, Oskar

AU - Johannesson, Haukur

AU - Ardenkjær-Larsen, Jan Henrik

AU - Laursen, Ib

PY - 2002/2/6

Y1 - 2002/2/6

N2 - The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising: (i) nuclear spin polarising a solid MR imaging agent (i.e. a material containing in its molecular structure a non-zero nuclear spin nucleus) by (a) spin refrigeration, or by, (b) irradiating with circularly polarised light; (ii) administering the nuclear spin polarised MR imaging agent to said sample, preferably after dissolution in a physiologically tolerable solvent and also preferably after separation form some or all of the paramagnetic species or chromophores; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in selected nuclei therein, e.g. the spin polarised nuclei of the MR imaging agent; (iv) detecting magnetic resonance signals form said sample; and (v) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (e.g. pH, pO2, pCO2, temperature or ionic concentrations) or metabolic data from said detected signals.

AB - The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising: (i) nuclear spin polarising a solid MR imaging agent (i.e. a material containing in its molecular structure a non-zero nuclear spin nucleus) by (a) spin refrigeration, or by, (b) irradiating with circularly polarised light; (ii) administering the nuclear spin polarised MR imaging agent to said sample, preferably after dissolution in a physiologically tolerable solvent and also preferably after separation form some or all of the paramagnetic species or chromophores; (iii) exposing said sample to a radiation at a frequency selected to excite nuclear spin transitions in selected nuclei therein, e.g. the spin polarised nuclei of the MR imaging agent; (iv) detecting magnetic resonance signals form said sample; and (v) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data (e.g. pH, pO2, pCO2, temperature or ionic concentrations) or metabolic data from said detected signals.

M3 - Patent

M1 - GB2364785

Y2 - 2002/02/06

ER -