Methods for producing monoterpene indole alkaloids

Michael Krogh Jensen; Lea Gram Hansen; Jie Zhang; Jay D Keasling; Samuel Alan Bradley; Vasil D'Ambrosio; Nils Emil Junge Marcussen

Methods for producing monoterpene indole alkaloids

Michael Krogh Jensen (Inventor), Lea Gram Hansen (Inventor), Jie Zhang (Inventor), Jay D Keasling (Inventor), Samuel Alan Bradley (Inventor), Vasil D'Ambrosio (Inventor), Nils Emil Junge Marcussen (Inventor)

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Abstract

The present invention relates to microorganisms for producing monoterpene indole al-kaloids (MIAs) and derivatives thereof de novo, including halogenated MIAs and halo-genated derivatives thereof. Also provided herein are methods for producing MIAs and derivatives thereof de novo, in particular halogenated MIAs and derivatives thereof, in a 5 microorganism, as well as useful nucleic acids, vectors and host cells for performing the present methods.

Original language	English
Patent number	WO2023222879
Filing date	07/07/2022
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	07/07/2022
Priority number	EP20220183656
Publication status	Published - 23 Nov 2023

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title = "Methods for producing monoterpene indole alkaloids",

abstract = "The present invention relates to microorganisms for producing monoterpene indole al-kaloids (MIAs) and derivatives thereof de novo, including halogenated MIAs and halo-genated derivatives thereof. Also provided herein are methods for producing MIAs and derivatives thereof de novo, in particular halogenated MIAs and derivatives thereof, in a 5 microorganism, as well as useful nucleic acids, vectors and host cells for performing the present methods.",

author = "Jensen, {Michael Krogh} and Hansen, {Lea Gram} and Jie Zhang and Keasling, {Jay D} and Bradley, {Samuel Alan} and Vasil D'Ambrosio and Marcussen, {Nils Emil Junge}",

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T1 - Methods for producing monoterpene indole alkaloids

AU - Jensen, Michael Krogh

AU - Hansen, Lea Gram

AU - Zhang, Jie

AU - Keasling, Jay D

AU - Bradley, Samuel Alan

AU - D'Ambrosio, Vasil

AU - Marcussen, Nils Emil Junge

PY - 2023/11/23

Y1 - 2023/11/23

N2 - The present invention relates to microorganisms for producing monoterpene indole al-kaloids (MIAs) and derivatives thereof de novo, including halogenated MIAs and halo-genated derivatives thereof. Also provided herein are methods for producing MIAs and derivatives thereof de novo, in particular halogenated MIAs and derivatives thereof, in a 5 microorganism, as well as useful nucleic acids, vectors and host cells for performing the present methods.

AB - The present invention relates to microorganisms for producing monoterpene indole al-kaloids (MIAs) and derivatives thereof de novo, including halogenated MIAs and halo-genated derivatives thereof. Also provided herein are methods for producing MIAs and derivatives thereof de novo, in particular halogenated MIAs and derivatives thereof, in a 5 microorganism, as well as useful nucleic acids, vectors and host cells for performing the present methods.

M3 - Patent

M1 - WO2023222879

Y2 - 2022/07/07

ER -

Methods for producing monoterpene indole alkaloids

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