Abstract
Embodiments of the present invention generally relate to the computational analysis and characterization biological networks at the cellular level in Chinese Hamster Ovary (CHO) cells. Based on computational methods utilizing a hamster reference genome, the invention provides methods for identifying a CHO cell line having a desired genetic trait, as well as for generating a desired CHO cell line having a genetic basis for a desired phenotype. Additionally, described herein are methods for constructing and analyzing in silico models of biological networks for CHO cells.
Original language | English |
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IPC | C12N5/07 |
Patent number | WO2015010088 |
Filing date | 22/01/2015 |
Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
Priority date | 19/07/2013 |
Priority number | US201361856526P |
Publication status | Published - 2015 |