The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.
|IPC||C12N1/21; C12N15/63; C12N9/88; C12P13/22; C12P21/02; C12P7/42|
|Country||International Bureau of the World Intellectual Property Organization (WIPO)|
|Publication status||Published - 2018|
Li, S., Jendresen, C. B., Pedersen, L. E., Landberg, J. M., Falkenberg, K. B., Mundhada, H., & Nielsen, A. T.
(2018). IPC No. C12N1/21; C12N15/63; C12N9/88; C12P13/22; C12P21/02; C12P7/42. Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides
. (Patent No. WO2018020012