Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides

Songyuan Li; Christian Bille Jendresen; Lasse Ebdrup Pedersen; Jenny Marie Landberg; Kristoffer Bach Falkenberg; Hemanshu Mundhada; Alex Toftgaard Nielsen

Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides

Songyuan Li (Inventor), Christian Bille Jendresen (Inventor), Lasse Ebdrup Pedersen (Inventor), Jenny Marie Landberg (Inventor), Kristoffer Bach Falkenberg (Inventor), Hemanshu Mundhada (Inventor), Alex Toftgaard Nielsen (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.

Original language	English
IPC	C12N1/21; C12N15/63; C12N9/88; C12P13/22; C12P21/02; C12P7/42
Patent number	WO2018020012
Filing date	01/02/2018
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	29/07/2016
Priority number	EP20160182046
Publication status	Published - 2018

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title = "Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides",

abstract = "The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.",

author = "Songyuan Li and Jendresen, {Christian Bille} and Pedersen, {Lasse Ebdrup} and Landberg, {Jenny Marie} and Falkenberg, {Kristoffer Bach} and Hemanshu Mundhada and Nielsen, {Alex Toftgaard}",

year = "2018",

language = "English",

type = "Patent",

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TY - PAT

T1 - Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides

AU - Li, Songyuan

AU - Jendresen, Christian Bille

AU - Pedersen, Lasse Ebdrup

AU - Landberg, Jenny Marie

AU - Falkenberg, Kristoffer Bach

AU - Mundhada, Hemanshu

AU - Nielsen, Alex Toftgaard

PY - 2018

Y1 - 2018

N2 - The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.

AB - The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.

M3 - Patent

M1 - WO2018020012

Y2 - 2018/02/01

ER -

Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides

Abstract

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