Methods and compound mixtures for determining protein activity using nmr spectroscopy

Bill Clark; Klaes Golman; Mathilde Hauge Lerche; Mike Looker; Mike O'Sullivan; Albie Santos; Rolf Servin; Mikkel Thanning; Jan Henrik Ardenkjær-Larsen

Methods and compound mixtures for determining protein activity using nmr spectroscopy

Bill Clark (Inventor), Klaes Golman (Inventor), Mathilde Hauge Lerche (Inventor), Mike Looker (Inventor), Mike O'Sullivan (Inventor), Albie Santos (Inventor), Rolf Servin (Inventor), Mikkel Thanning (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor)

Research output: Patent

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Abstract

The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed "hyperpolarisation") prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.

Original language	English
IPC	G01R 33/ 28 A I
Patent number	US2005233470
Filing date	20/10/2005
Country/Territory	United States
Priority date	15/04/2003
Priority number	WO2003NO00125
Publication status	Published - 20 Oct 2005
Externally published	Yes

Bibliographical note

Also published as: WO03089656 (A1) JP2005523441 (A) EP1497448 (A1) AU2003228149 (A1) AU2003228149 (A8)

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US2005233470A1 proteinactivityFinal published version, 1.24 MB

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Clark, Bill (Inventor) ; Golman, Klaes (Inventor) ; Lerche, Mathilde Hauge (Inventor) ; Looker, Mike (Inventor) ; O'Sullivan, Mike (Inventor) ; Santos, Albie (Inventor) ; Servin, Rolf (Inventor) ; Thanning, Mikkel (Inventor) ; Ardenkjær-Larsen, Jan Henrik (Inventor). / Methods and compound mixtures for determining protein activity using nmr spectroscopy. Patent No.: US2005233470. Oct 20, 2005.

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title = "Methods and compound mixtures for determining protein activity using nmr spectroscopy",

abstract = "The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed {"}hyperpolarisation{"}) prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.",

author = "Bill Clark and Klaes Golman and Lerche, {Mathilde Hauge} and Mike Looker and Mike O'Sullivan and Albie Santos and Rolf Servin and Mikkel Thanning and Ardenkj{\ae}r-Larsen, {Jan Henrik}",

note = "Also published as: WO03089656 (A1) JP2005523441 (A) EP1497448 (A1) AU2003228149 (A1) AU2003228149 (A8) ; US2005233470; G01R 33/ 28 A I",

year = "2005",

month = oct,

day = "20",

language = "English",

type = "Patent",

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Methods and compound mixtures for determining protein activity using nmr spectroscopy. / Clark, Bill (Inventor); Golman, Klaes (Inventor); Lerche, Mathilde Hauge (Inventor); Looker, Mike (Inventor); O'Sullivan, Mike (Inventor); Santos, Albie (Inventor); Servin, Rolf (Inventor); Thanning, Mikkel (Inventor); Ardenkjær-Larsen, Jan Henrik (Inventor).

Patent No.: US2005233470. Oct 20, 2005.

Research output: Patent

TY - PAT

T1 - Methods and compound mixtures for determining protein activity using nmr spectroscopy

AU - Clark, Bill

AU - Golman, Klaes

AU - Lerche, Mathilde Hauge

AU - Looker, Mike

AU - O'Sullivan, Mike

AU - Santos, Albie

AU - Servin, Rolf

AU - Thanning, Mikkel

AU - Ardenkjær-Larsen, Jan Henrik

N1 - Also published as: WO03089656 (A1) JP2005523441 (A) EP1497448 (A1) AU2003228149 (A1) AU2003228149 (A8)

PY - 2005/10/20

Y1 - 2005/10/20

N2 - The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed "hyperpolarisation") prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.

AB - The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed "hyperpolarisation") prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.

M3 - Patent

M1 - US2005233470

Y2 - 2005/10/20

ER -

Methods and compound mixtures for determining protein activity using nmr spectroscopy

Abstract

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