Methods and compound mixtures for determining protein activity using nmr spectroscopy

Bill Clark (Inventor), Klaes Golman (Inventor), Mathilde Hauge Lerche (Inventor), Mike Looker (Inventor), Mike O'Sullivan (Inventor), Albie Santos (Inventor), Rolf Servin (Inventor), Mikkel Thanning (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor)

Research output: Patent

30 Downloads (Pure)

Abstract

The invention relates to methods for determining protein activity using NMR spectroscopy. The present invention provides a method for determining protein activity in vivo using probe compounds and enhancing the nuclear polarisation of NMR active nuclei present in the probe compounds (hereinafter termed "hyperpolarisation") prior to NMR analysis. The invention also provides mixtures of probe compounds for the above-mentioned method.

Original languageEnglish
IPCG01R 33/ 28 A I
Patent numberUS2005233470
Filing date20/10/2005
Country/TerritoryUnited States
Priority date15/04/2003
Priority numberWO2003NO00125
Publication statusPublished - 20 Oct 2005
Externally publishedYes

Bibliographical note

Also published as: WO03089656 (A1) JP2005523441 (A) EP1497448 (A1) AU2003228149 (A1) AU2003228149 (A8)

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