Methodological Approach for Modeling of Multienzyme in-pot Processes

Paloma de Gracia Andrade Santacoloma, Alicia Roman Martinez, Gürkan Sin, Krist Gernaey, John Woodley

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Abstract

This paper presents a methodological approach for modeling multi-enzyme in-pot processes. The methodology is exemplified stepwise through the bi-enzymatic production of N-acetyl-D-neuraminic acid (Neu5Ac) from N-acetyl-D-glucosamine (GlcNAc). In this case study, sensitivity analysis is also used to evaluate the reliability of all parameters of the model suggested in literature [5], Results, from the sensitivity analysis, are used as criteria for a systematic simplification of the model structure. Consequently, model complexity was reduced without compromising the general predictive performance. A deviation of less than 5% from the original model was found.
Original languageEnglish
Title of host publication21st European Symposium on Computer Aided Process Engineering
PublisherElsevier
Publication date2011
Pages1346-1350
ISBN (Print)978-0-444-53895-6
DOIs
Publication statusPublished - 2011
Event21st European Symposium on Computer Aided Process Engineering - Chalkidiki, Greece
Duration: 29 May 20111 Jun 2011
http://www.escape-21.gr/

Conference

Conference21st European Symposium on Computer Aided Process Engineering
CountryGreece
CityChalkidiki
Period29/05/201101/06/2011
Internet address
SeriesComputer Aided Chemical Engineering
Number29
ISSN1570-7946

Keywords

  • Multi-enzyme in-pot
  • Neu5Ac production
  • Mathematical model

Fingerprint Dive into the research topics of 'Methodological Approach for Modeling of Multienzyme in-pot Processes'. Together they form a unique fingerprint.

Cite this