Method for the production of l-serine using genetically engineered microorganisms deficient in serine degradation pathways.

Hemanshu Mundhada (Inventor), Alex Toftgaard Nielsen (Inventor)

Research output: Patent

Abstract

The present invention generally relates to the microbiological industry, and specifically to the production of L-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.

Original languageEnglish
IPCC12N 15/ 00 A I
Patent numberWO2016120326
Filing date04/08/2016
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date27/01/2015
Priority numberEP20150152643
Publication statusPublished - 4 Aug 2016

Bibliographical note

Also published as: WO2016120345 (A1)

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