Method for the detection of aquaretic compounds

Thomas Jonassen; Niels Hadrup; Jørgen Søberg Petersen

Method for the detection of aquaretic compounds

Thomas Jonassen (Inventor)
, Niels Hadrup (Inventor)
, Jørgen Søberg Petersen (Inventor)

National Food Institute

Research output: Patent

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Abstract

Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of
uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.

Original language	English
IPC	A61K38/08
Patent number	WO2003097857
Filing date	27/03/2003
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Publication status	Published - 2003

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AU - Hadrup, Niels

AU - Petersen, Jørgen Søberg

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AB - Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.

M3 - Patent

M1 - WO2003097857

Y2 - 2003/03/27

ER -

Method for the detection of aquaretic compounds

Abstract

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