Abstract
Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of
uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.
uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.
| Original language | English |
|---|---|
| IPC | A61K38/08 |
| Patent number | WO2003097857 |
| Filing date | 27/03/2003 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Publication status | Published - 2003 |