Method for the detection of aquaretic compounds

Thomas Jonassen (Inventor), Niels Hadrup (Inventor), Jørgen Søberg Petersen (Inventor)

Research output: Patent

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Abstract

Disclosed is a method for detecting an aquaretic compound. In one embodiment, the method includes administering to a mammal a candidate compound that modulates a nociceptin receptor. Biological material is isolated from the mammal and expression of aquaporin-2 is measured. Modulation of the aquaporin-2 is taken to be indicative of a candidate compound having aquaretic activity. The invention has a wide spectrum of
uses including helping to identify new diuretics that spare unwanted loss of sodium and potassium ions.
Original languageEnglish
IPCA61K38/08
Patent numberWO2003097857
Filing date27/03/2003
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Publication statusPublished - 2003

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