Method for reducing ammonium and lactate production in cho cells

Daniel Ley (Inventor), Mikael Rørdam Andersen (Inventor), Helene Faustrup Kildegaard (Inventor)

Research output: Patent

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Abstract

The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

Original languageEnglish
IPCC12N15/52; C12P21/02
Patent numberWO2018033542
Filing date22/02/2018
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date15/08/2016
Priority numberEP20160184179
Publication statusPublished - 2018

Cite this

Ley, D., Andersen, M. R., & Kildegaard, H. F. (2018). IPC No. C12N15/52; C12P21/02. Method for reducing ammonium and lactate production in cho cells. (Patent No. WO2018033542).
Ley, Daniel (Inventor) ; Andersen, Mikael Rørdam (Inventor) ; Kildegaard, Helene Faustrup (Inventor). / Method for reducing ammonium and lactate production in cho cells. IPC No.: C12N15/52; C12P21/02. Patent No.: WO2018033542. Feb 22, 2018.
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Ley, D, Andersen, MR & Kildegaard, HF Feb. 22 2018, Method for reducing ammonium and lactate production in cho cells, Patent No. WO2018033542, IPC No. C12N15/52; C12P21/02.

Method for reducing ammonium and lactate production in cho cells. / Ley, Daniel (Inventor); Andersen, Mikael Rørdam (Inventor); Kildegaard, Helene Faustrup (Inventor).

IPC No.: C12N15/52; C12P21/02. Patent No.: WO2018033542. Feb 22, 2018.

Research output: Patent

TY - PAT

T1 - Method for reducing ammonium and lactate production in cho cells

AU - Ley, Daniel

AU - Andersen, Mikael Rørdam

AU - Kildegaard, Helene Faustrup

PY - 2018

Y1 - 2018

N2 - The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

AB - The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

M3 - Patent

M1 - WO2018033542

Y2 - 2018/02/22

ER -

Ley D, Andersen MR, Kildegaard HF, inventors. Method for reducing ammonium and lactate production in cho cells. C12N15/52; C12P21/02. 2018.