Method for reducing ammonium and lactate production in cho cells

Daniel Ley (Inventor), Mikael Rørdam Andersen (Inventor), Helene Faustrup Kildegaard (Inventor)

Research output: Patent

221 Downloads (Pure)


The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.

Original languageEnglish
IPCC12N15/52; C12P21/02
Patent numberWO2018033542
Filing date22/02/2018
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date15/08/2016
Priority numberEP20160184179
Publication statusPublished - 2018

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