Abstract
The present invention relates to modified producer cells for improved production of therapeutic proteins. Specifically, the inventors have found that removing genes involved in amino acid catabolism in Chinese Hamster Ovary (CHO) cells improves the cell growth and viability and likely also the yield of a recombinant therapeutic protein produced by the cells.
| Original language | English |
|---|---|
| IPC | C12N15/52; C12P21/02 |
| Patent number | WO2018033542 |
| Filing date | 22/02/2018 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 15/08/2016 |
| Priority number | EP20160184179 |
| Publication status | Published - 2018 |