Method for phenotyping using nmr spectroscopy

Bill Clark; Klaes Golman; Mathilde Hauge Lerche; Mike Looker; Mike O'Sullivan; Albie Santos; Rolf Servin; Mikkel Thanning; Jan Henrik Ardenkjær-Larsen

Method for phenotyping using nmr spectroscopy

Bill Clark (Inventor)
, Klaes Golman (Inventor)
, Mathilde Hauge Lerche (Inventor)
, Mike Looker (Inventor)
, Mike O'Sullivan (Inventor)
, Albie Santos (Inventor)
, Rolf Servin (Inventor)
, Mikkel Thanning (Inventor)
, Jan Henrik Ardenkjær-Larsen (Inventor)

GE Healthcare

Research output: Patent

101 Downloads (Orbit)

Abstract

The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed "hyperpolarisation") prior to NMR analysis.

Original language	English
IPC	G01R 33/ 465 A I
Patent number	US2005232864
Filing date	13/05/2005
Country/Territory	United States
Priority date	15/04/2003
Priority number	WO2003NO00126
Publication status	Published - 20 Oct 2005
Externally published	Yes

Bibliographical note

Also published as: WO03089657 (A1) JP2005523442 (A) JP4424656 (B2) EP1501940 (A1) AU2003228150 (A1) AU2003228150 (A8)

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title = "Method for phenotyping using nmr spectroscopy",

abstract = "The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed {"}hyperpolarisation{"}) prior to NMR analysis.",

author = "Bill Clark and Klaes Golman and Lerche, \{Mathilde Hauge\} and Mike Looker and Mike O'Sullivan and Albie Santos and Rolf Servin and Mikkel Thanning and Ardenkj{\ae}r-Larsen, \{Jan Henrik\}",

note = "Also published as: WO03089657 (A1) JP2005523442 (A) JP4424656 (B2) EP1501940 (A1) AU2003228150 (A1) AU2003228150 (A8) ; US2005232864; G01R 33/ 465 A I",

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T1 - Method for phenotyping using nmr spectroscopy

AU - Clark, Bill

AU - Golman, Klaes

AU - Lerche, Mathilde Hauge

AU - Looker, Mike

AU - O'Sullivan, Mike

AU - Santos, Albie

AU - Servin, Rolf

AU - Thanning, Mikkel

AU - Ardenkjær-Larsen, Jan Henrik

N1 - Also published as: WO03089657 (A1) JP2005523442 (A) JP4424656 (B2) EP1501940 (A1) AU2003228150 (A1) AU2003228150 (A8)

PY - 2005/10/20

Y1 - 2005/10/20

N2 - The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed "hyperpolarisation") prior to NMR analysis.

AB - The invention relates to methods for phenotyping by determining protein activity in vivo using at least one probe compound and enhancing the nuclear polarisation of NMR active nuclei present in the probe compound (hereinafter termed "hyperpolarisation") prior to NMR analysis.

M3 - Patent

M1 - US2005232864

Y2 - 2005/05/13

ER -

Method for phenotyping using nmr spectroscopy

Abstract

Bibliographical note

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