Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei.

Neil Cook; Albie Santos; Nigel Bosworth; Jan Wolber; Mike Looker; Peter Knox; Jan Henrik Ardenkjær-Larsen; Klaes Golman

Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei.

Neil Cook (Inventor), Albie Santos (Inventor), Nigel Bosworth (Inventor), Jan Wolber (Inventor), Mike Looker (Inventor), Peter Knox (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor), Klaes Golman (Inventor)

Nycomed Amersham Plc

Research output: Patent

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Abstract

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarisation methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

Original language	English
IPC	G01R 33/ 465 A I
Patent number	WO0196895
Filing date	20/01/2001
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	14/06/2000
Priority number	GB20000014463
Publication status	Published - 20 Dec 2001
Externally published	Yes

Bibliographical note

Also published as: US2004039281 (A1) US8372654 (B2) JP2004503786 (A) JP4993424 (B2) ES2381335 (T3) EP1290461 (A1) EP1290461 (B1) AU6407201 (A) AT549637 (T)

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title = "Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei.",

abstract = "The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarisation methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.",

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T1 - Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei.

AU - Cook, Neil

AU - Santos, Albie

AU - Bosworth, Nigel

AU - Wolber, Jan

AU - Looker, Mike

AU - Knox, Peter

AU - Ardenkjær-Larsen, Jan Henrik

AU - Golman, Klaes

N1 - Also published as: US2004039281 (A1) US8372654 (B2) JP2004503786 (A) JP4993424 (B2) ES2381335 (T3) EP1290461 (A1) EP1290461 (B1) AU6407201 (A) AT549637 (T)

PY - 2001/12/20

Y1 - 2001/12/20

N2 - The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarisation methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

AB - The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarisation methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

M3 - Patent

M1 - WO0196895

Y2 - 2001/01/20

ER -

Method for investigating the fate of a test compound or the stateof a biological system by means of nmr of hyperpolarised nmr active nuclei.

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