Abstract
An NMR based method for characterising the metabolic stability of a drug candidate comprising the steps of enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed "hyperpolarisation"), contacting the drug candidate with liver cells or cell organelles, and carrying out NMR analysis.
Original language | English |
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IPC | G01R 33/ 62 A N |
Patent number | US2005170331 |
Filing date | 04/08/2005 |
Country/Territory | United States |
Priority date | 17/12/2003 |
Priority number | NO20030005626 |
Publication status | Published - 4 Aug 2005 |
Externally published | Yes |