Method and apparatus for producing contrast agents for magnetic resonance imaging

Jan Henrik Ardenkjær-Larsen (Inventor), Oskar Axelsson (Inventor), Haukur Jóhannesson (Inventor)

    Research output: Patent

    25 Downloads (Pure)


    The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120, 305) the contrast agent to a sequence of pulses of magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing pulses of magnetic field.
    Original languageEnglish
    IPCA61B5/055; A61K49/00; A61K49/18; G01R33/28; (IPC1-7): A61K49/06
    Patent numberWO2004019997
    Filing date11/03/2004
    Priority date29/08/2002
    Priority numberGB20020019952
    Publication statusPublished - 2004

    Bibliographical note

    Also published as: AT355085 (T) AU2003264127 (A1) CN1694731 (A) DE60312172 (T2) EP1531872 (A1) EP1531872 (B1) JP2005536306 (A) US2006104906 (A1)


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