The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.
|IPC||A61K49/00; A61K49/06; (IPC1-7): A61K49/00|
|Publication status||Published - 2004|
Bibliographical noteAlso published as: WO2004019995 (A3) AT335514 (T) AU2003258687 (A1) AU2003258687 (A8) CN100335139 (C) CN1694730 (A) DE60307477 (T2) EP1531871 (A2) EP1531871 (B1) JP2006510585 (A) US2006127313 (A1)
Goldman, M., Axelsson, O., Jóhannesson, H., & Ardenkjær-Larsen, J. H. (2004). IPC No. A61K49/00; A61K49/06; (IPC1-7): A61K49/00. Method and apparatus for producing contrast agents for magnetic resonance imaging. (Patent No. WO2004019995 ).