Method and apparatus for producing contrast agents for magnetic resonance imaging

Maurice Goldman; Oskar Axelsson; Haukur Jóhannesson; Jan Henrik Ardenkjær-Larsen

Method and apparatus for producing contrast agents for magnetic resonance imaging

Maurice Goldman (Inventor), Oskar Axelsson (Inventor), Haukur Jóhannesson (Inventor), Jan Henrik Ardenkjær-Larsen (Inventor)

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Abstract

The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.

Original language	English
IPC	A61K49/00; A61K49/06; (IPC1-7): A61K49/00
Patent number	WO2004019995
Filing date	11/03/2004
Priority date	29/08/2002
Priority number	GB20020019954
Publication status	Published - 2004

Bibliographical note

Also published as: WO2004019995 (A3) AT335514 (T) AU2003258687 (A1) AU2003258687 (A8) CN100335139 (C) CN1694730 (A) DE60307477 (T2) EP1531871 (A2) EP1531871 (B1) JP2006510585 (A) US2006127313 (A1)

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title = "Method and apparatus for producing contrast agents for magnetic resonance imaging",

abstract = "The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.",

author = "Maurice Goldman and Oskar Axelsson and Haukur J{\'o}hannesson and Ardenkj{\ae}r-Larsen, {Jan Henrik}",

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TY - PAT

T1 - Method and apparatus for producing contrast agents for magnetic resonance imaging

AU - Goldman, Maurice

AU - Axelsson, Oskar

AU - Jóhannesson, Haukur

AU - Ardenkjær-Larsen, Jan Henrik

N1 - Also published as: WO2004019995 (A3) AT335514 (T) AU2003258687 (A1) AU2003258687 (A8) CN100335139 (C) CN1694730 (A) DE60307477 (T2) EP1531871 (A2) EP1531871 (B1) JP2006510585 (A) US2006127313 (A1)

PY - 2004

Y1 - 2004

N2 - The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.

AB - The present invention relates to an arrangement and a method for providing contrast agent for e.g. MRI (Magnetic Resonance Imaging) and NMR (Nuclear Magnetic Resonance) applications. The method according to the invention comprises the steps of obtaining (100) a solution in a solvent of a hydrogenatable, unsaturated substrate compound and a catalyst for the hydrogenation of a substrate compound, hydrogenating (110) the substrate with hydrogen gas (H2) enriched in para-hydrogen (p-1H2) to form a hydrogenated contrast agent and exposing (120) the contrast agent to a oscillating magnetic field in combination with a stationary magnetic field. The apparatus comprises a magnetic treatment unit (240) equipped with means for producing an oscillating and a stationary magnetic field.

M3 - Patent

M1 - WO2004019995

Y2 - 2004/03/11

ER -

Method and apparatus for producing contrast agents for magnetic resonance imaging

Abstract

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