Methimazole and amitrole disrupt the thyroid hormone system and brain development

L Ramhøj; T Svingen; C Frädrich; E Rijntjes; E Wirth; K Pedersen; J Köhrle; M Axelstad

Methimazole and amitrole disrupt the thyroid hormone system and brain development

L Ramhøj
, T Svingen
, C Frädrich
, E Rijntjes
, E Wirth
, K Pedersen
, J Köhrle
, M Axelstad

Research output: Contribution to conference › Poster › Research

Abstract

We have identified a common effect pattern for TPO inhibiting chemicals that can alter brain development through thyroid hormone system disruption. This study, and future studies arising from it, will provide a solid foundation for developing new sensitive test methods for the regulation of thyroid hormone system disrupting chemicals. Such methods are critical to enable the regulatory system to protect human brain development from environmental chemicals with thyroid hormone system disrupting properties.

Original language	English
Publication date	2022
Number of pages	1
Publication status	Published - 2022
Event	EURION (European cluster to improve identification of endocrine disruptors) Annual Meeting 2022 - Online Duration: 20 Jan 2022 → 21 Jan 2022

Conference

Conference	EURION (European cluster to improve identification of endocrine disruptors) Annual Meeting 2022
Location	Online
Period	20/01/2022 → 21/01/2022

OpenUrl availability

Full text

Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring
Ramhøj, L., Svingen, T., Frädrich, C., Rijntjes, E., Wirth, E. K., Pedersen, K., Köhrle, J. & Axelstad, M., 2022, In: Toxicology Letters. 354, p. 44-55 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review

Open Access
File
158 Downloads (Orbit)

Cite this

@conference{f40f5fe0cd794a5592d705176573e14b,

title = "Methimazole and amitrole disrupt the thyroid hormone system and brain development",

abstract = "We have identified a common effect pattern for TPO inhibiting chemicals that can alter brain development through thyroid hormone system disruption. This study, and future studies arising from it, will provide a solid foundation for developing new sensitive test methods for the regulation of thyroid hormone system disrupting chemicals. Such methods are critical to enable the regulatory system to protect human brain development from environmental chemicals with thyroid hormone system disrupting properties.",

author = "L Ramh{\o}j and T Svingen and C Fr{\"a}drich and E Rijntjes and E Wirth and K Pedersen and J K{\"o}hrle and M Axelstad",

year = "2022",

language = "English",

note = "<br/>EURION (European cluster to improve identification of endocrine disruptors) Annual Meeting 2022 ; Conference date: 20-01-2022 Through 21-01-2022",

}

TY - CONF

T1 - Methimazole and amitrole disrupt the thyroid hormone system and brain development

AU - Ramhøj, L

AU - Svingen, T

AU - Frädrich, C

AU - Rijntjes, E

AU - Wirth, E

AU - Pedersen, K

AU - Köhrle, J

AU - Axelstad, M

PY - 2022

Y1 - 2022

N2 - We have identified a common effect pattern for TPO inhibiting chemicals that can alter brain development through thyroid hormone system disruption. This study, and future studies arising from it, will provide a solid foundation for developing new sensitive test methods for the regulation of thyroid hormone system disrupting chemicals. Such methods are critical to enable the regulatory system to protect human brain development from environmental chemicals with thyroid hormone system disrupting properties.

AB - We have identified a common effect pattern for TPO inhibiting chemicals that can alter brain development through thyroid hormone system disruption. This study, and future studies arising from it, will provide a solid foundation for developing new sensitive test methods for the regulation of thyroid hormone system disrupting chemicals. Such methods are critical to enable the regulatory system to protect human brain development from environmental chemicals with thyroid hormone system disrupting properties.

M3 - Poster

T2 - <br/>EURION (European cluster to improve identification of endocrine disruptors) Annual Meeting 2022

Y2 - 20 January 2022 through 21 January 2022

ER -

Methimazole and amitrole disrupt the thyroid hormone system and brain development

Abstract

Conference

OpenUrl availability

Fingerprint

Research output

Perinatal exposure to the thyroperoxidase inhibitors methimazole and amitrole perturbs thyroid hormone system signaling and alters motor activity in rat offspring

Cite this