Metatranscriptomics of the human gut microbiome

Thomas Sicheritz-Pontén (Invited author)

Research output: Contribution to journalConference abstract in journalResearch


Our ‘other’ genome is the collective genetic information in all of the microorganisms that are living on and within us. Collectively known as the microbiome, these microbial cells outnumber human cells in the body by more than 10 to 1, and the genes carried by these organisms outnumber the genes in the human genome by more than 100 to 1.

How these organisms contribute to and affect human health is poorly understood, but the emerging field of metagenomics promises a more comprehensive and complete understanding of the human microbiome. In the European-funded Metagenomics of the Human Intestinal Tract (MetaHIT) project [1], we combined next-generation sequencing with high-density microarrays, generating metagenomic and metatranscriptomic data for more than 400 individuals.

The combined data reveal clusters of coexisting species with differences in pathway and gene function activity, suggesting that there is a division of labor between the bacterial species in the human gut microbiome.
Original languageEnglish
JournalGenome Biology (Online Edition)
Volume12 Suppl 1
Pages (from-to)I15
Publication statusPublished - 2011

Bibliographical note

Invited speaker presentation


Dive into the research topics of 'Metatranscriptomics of the human gut microbiome'. Together they form a unique fingerprint.

Cite this