Metabolomics of Aspergillus fumigatus

Jens Christian Frisvad, Christian Rank, Kristian Fog Nielsen, Thomas Ostenfeld Larsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Aspergillus fumigatus is the most important species in Aspergillus causing infective lung diseases. This species has been reported to produce a large number of extrolites, including secondary metabolites, acids, and proteins such as hydrophobins and extracellular enzymes. At least 226 potentially bioactive secondary metabolites have been reported from A. fumigatus that can be ordered into 24 biosynthetic families. Of these families we have detected representatives from the following families of secondary metabolites: fumigatins, fumigaclavines, fumiquinazolines, trypacidin and monomethylsulochrin, fumagillins, gliotoxins, pseurotins, chloroanthraquinones, fumitremorgins, verruculogen, helvolic acids, and pyripyropenes by HPLC with diode array detection and mass spectrometric detection. There is still doubt whether A. fumigatus can produce tryptoquivalins, but all isolates produce the related fumiquinazolines. We also tentatively detected sphingofungins in A. fumigatus Af293 and in an isolate of A. lentulus. The sphingofungins may have a similar role as the toxic fumonisins, found in A. niger. A further number of mycotoxins, including ochratoxin A, and other secondary metabolites have been reported from A. fumigatus, but in those cases either the fungus or its metabolite appear to be misidentified.
    Original languageEnglish
    JournalMedical Mycology
    Volume47
    Issue number1
    Pages (from-to)S53-S71
    ISSN1369-3786
    DOIs
    Publication statusPublished - 2009

    Keywords

    • extrolites
    • sphingofungin
    • Aspergillus section Fumigati
    • Metabolomics

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