Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages

Kristian Fog Nielsen, K. Huttunen, A. Hyvarinen, Birgitte Andersen, B.B. Jarvis, M.R. Hirvonen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The metabolite profiles of 20 Stachybotrys spp. isolates from Finnish water-damaged buildings were compared with their biological activities. Effects of purified compounds on cytotoxicity and production of inflammatory mediators such as nitric oxide, IL-6 and TNFalpha in murine RAW264.7 macrophage cells were studied. The 11 isolates belonging to the satratoxin-producing chemotype were highly cytotoxic to the macrophages. The isolates inducing inflammatory mediators all belonged to the atranone-producing chemotype, but pure atranones B, and D did not elicit a response in the bioassay. Altogether, cytotoxicity of Stachybotrys sp. isolates appear to be related to satratoxin production whereas the specific component inducing inflammatory responses in atranone-producing isolates remains obscure.
    Original languageEnglish
    JournalMycopathologia
    Volume154
    Issue number4
    Pages (from-to)201-205
    ISSN0301-486X
    DOIs
    Publication statusPublished - 2002

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