Metabolite Depletion Affects Flux Profiling of Cell Lines

A. Nilsson, J. R. Haanstra, B. Teusink, J. Nielsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.
Original languageEnglish
JournalTrends in Biochemical Sciences
Volume43
Issue number6
Pages (from-to)395-397
Number of pages3
ISSN0968-0004
DOIs
Publication statusPublished - 2018

Keywords

  • Cancer
  • Glutamine
  • Metabolic modeling
  • Serine

Cite this

Nilsson, A. ; Haanstra, J. R. ; Teusink, B. ; Nielsen, J. / Metabolite Depletion Affects Flux Profiling of Cell Lines. In: Trends in Biochemical Sciences. 2018 ; Vol. 43, No. 6. pp. 395-397.
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Metabolite Depletion Affects Flux Profiling of Cell Lines. / Nilsson, A.; Haanstra, J. R.; Teusink, B.; Nielsen, J.

In: Trends in Biochemical Sciences, Vol. 43, No. 6, 2018, p. 395-397.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Metabolite Depletion Affects Flux Profiling of Cell Lines

AU - Nilsson, A.

AU - Haanstra, J. R.

AU - Teusink, B.

AU - Nielsen, J.

PY - 2018

Y1 - 2018

N2 - Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

AB - Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

KW - Cancer

KW - Glutamine

KW - Metabolic modeling

KW - Serine

U2 - 10.1016/j.tibs.2018.03.009

DO - 10.1016/j.tibs.2018.03.009

M3 - Journal article

VL - 43

SP - 395

EP - 397

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

SN - 0968-0004

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