Metabolite Depletion Affects Flux Profiling of Cell Lines

A. Nilsson; J. R. Haanstra; B. Teusink; J. Nielsen

doi:10.1016/j.tibs.2018.03.009

Metabolite Depletion Affects Flux Profiling of Cell Lines

A. Nilsson, J. R. Haanstra, B. Teusink, J. Nielsen^*

^*Corresponding author for this work

Novo Nordisk Foundation Center for Biosustainability

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

Original language	English
Journal	Trends in Biochemical Sciences
Volume	43
Issue number	6
Pages (from-to)	395-397
ISSN	0968-0004
DOIs	https://doi.org/10.1016/j.tibs.2018.03.009
Publication status	Published - 2018

Keywords

Cancer
Glutamine
Metabolic modeling
Serine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tibs.2018.03.009

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title = "Metabolite Depletion Affects Flux Profiling of Cell Lines",

abstract = "Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.",

keywords = "Cancer, Glutamine, Metabolic modeling, Serine",

author = "A. Nilsson and Haanstra, {J. R.} and B. Teusink and J. Nielsen",

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AU - Nilsson, A.

AU - Haanstra, J. R.

AU - Teusink, B.

AU - Nielsen, J.

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Y1 - 2018

N2 - Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

AB - Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.

KW - Cancer

KW - Glutamine

KW - Metabolic modeling

KW - Serine

U2 - 10.1016/j.tibs.2018.03.009

DO - 10.1016/j.tibs.2018.03.009

M3 - Journal article

C2 - 29656822

SN - 0968-0004

VL - 43

SP - 395

EP - 397

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Metabolite Depletion Affects Flux Profiling of Cell Lines

Abstract

Keywords

UN SDGs

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