Quantifying the rate of consumption and release of metabolites (i.e., flux profiling) has become integral to the study of cancer. The fluxes as well as the growth of the cells may be affected by metabolite depletion during cultivation.
- Metabolic modeling
Nilsson, A., Haanstra, J. R., Teusink, B., & Nielsen, J. (2018). Metabolite Depletion Affects Flux Profiling of Cell Lines. Trends in Biochemical Sciences, 43(6), 395-397. https://doi.org/10.1016/j.tibs.2018.03.009