Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

Jochen Förster; Nina Katarina Gunnarsson; Elisabeth Malin  Svensson; Helga Susana Moreira David; Iben Plate; Pere Tavares Sabina  de Andrade; Jean-Marie Mouillion; Sara Petersen Bjørn; Per Møller

Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

Jochen Förster (Inventor), Nina Katarina Gunnarsson (Inventor), Elisabeth Malin Svensson (Inventor), Helga Susana Moreira David (Inventor), Iben Plate (Inventor), Pere Tavares Sabina de Andrade (Inventor), Jean-Marie Mouillion (Inventor), Sara Petersen Bjørn (Inventor), Per Møller (Inventor)

Research output: Patent

86 Downloads (Pure)

Abstract

This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases.

Original language	English
IPC	US20060817643P
Patent number	WO2008000277
Filing date	03/01/2008
Country	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	29/06/2007
Priority number	US20060817643P
Publication status	Published - 2008

Access to Document

WO2008000277A2Final published version, 5.83 MB

Fingerprint Dive into the research topics of 'Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids'. Together they form a unique fingerprint.

Cite this

Förster, Jochen (Inventor) ; Gunnarsson, Nina Katarina (Inventor) ; Svensson, Elisabeth Malin (Inventor) ; David, Helga Susana Moreira (Inventor) ; Plate, Iben (Inventor) ; de Andrade, Pere Tavares Sabina (Inventor) ; Mouillion, Jean-Marie (Inventor) ; Petersen Bjørn, Sara (Inventor) ; Møller, Per (Inventor). / Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids. Patent No.: WO2008000277.

@misc{3611a7e540974c32a657893476eb29ed,

title = "Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids",

abstract = "This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases.",

author = "Jochen F{\"o}rster and Gunnarsson, {Nina Katarina} and Svensson, {Elisabeth Malin} and David, {Helga Susana Moreira} and Iben Plate and {de Andrade}, {Pere Tavares Sabina} and Jean-Marie Mouillion and {Petersen Bj{\o}rn}, Sara and Per M{\o}ller",

year = "2008",

language = "English",

type = "Patent",

note = " WO2008000277; US20060817643P",

}

Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids. / Förster, Jochen (Inventor); Gunnarsson, Nina Katarina (Inventor); Svensson, Elisabeth Malin (Inventor); David, Helga Susana Moreira (Inventor); Plate, Iben (Inventor); de Andrade, Pere Tavares Sabina (Inventor); Mouillion, Jean-Marie (Inventor); Petersen Bjørn, Sara (Inventor); Møller, Per (Inventor).

Patent No.: WO2008000277.

Research output: Patent

TY - PAT

T1 - Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

AU - Förster, Jochen

AU - Gunnarsson, Nina Katarina

AU - Svensson, Elisabeth Malin

AU - David, Helga Susana Moreira

AU - Plate, Iben

AU - de Andrade, Pere Tavares Sabina

AU - Mouillion, Jean-Marie

AU - Petersen Bjørn, Sara

AU - Møller, Per

PY - 2008

Y1 - 2008

N2 - This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases.

AB - This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases.

M3 - Patent

M1 - WO2008000277

Y2 - 2008/01/03

ER -