Metabolically Engineered Fungal Cells With Increased Content Of Polyunsaturated Fatty Acids

Jochen Förster (Inventor), Nina Katarina Gunnarsson (Inventor), Elisabeth Malin Svensson (Inventor), Helga Susana Moreira David (Inventor), Iben Plate (Inventor), Pere Tavares Sabina de Andrade (Inventor), Jean-Marie Mouillion (Inventor), Sara Petersen Bjørn (Inventor), Per Møller (Inventor)

    Research output: Patent

    86 Downloads (Pure)

    Abstract

    This invention relates to the production of fatty acids and particularly to the production of the polyunsaturated fatty acids (PUFAs) arachidonic acid (ARA) and eicosapentaenoic acid (EPA) in genetically engineered fungal cells, in particular, to metabolically engineered Saccharomyces cerevisiae cells with increased content of ARA and EPA. The invention especially involves improvement of the PUFA content in the host organism through various over-expression of e.g. cytochrome b5 and cytochrome b5 reductase involved in fatty acid desaturation, and heterologous expression of cytochrome b5 and cytochrome b5 reductase and expression of heterologous fatty acid synthases.
    Original languageEnglish
    IPCUS20060817643P
    Patent number WO2008000277
    Filing date03/01/2008
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date29/06/2007
    Priority numberUS20060817643P
    Publication statusPublished - 2008

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