Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof

Michael Katz (Inventor), Hans Peter Smits (Inventor), Jochen Förster (Inventor), Jens Bredal Nielsen (Inventor)

Research output: Patent

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Abstract

A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4- hydroxylase (C4H) produces 4-coumaric acid from said trans- cinnamic acid, 4-coumarate-CoA ligase (4CL) produces 4- coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4- coumaroyl CoA, or in which L-phenylalanine- or tyrosine- ammonia lyase (PAL/TAL) produces 4-coumaric acid, 4- coumarate-CoA ligase (4CL) produces 4-coumaroyl CoA from said 4-coumaric acid, and resveratrol synthase (VST) produces said resveratrol from said 4-coumaroyl CoA. The micro-organism may be a yeast, fungus or bacterium including Saccharomyces cerevisiae, E. coli, Lactococcus lactis, Aspergillus niger, or Aspergillus oryzae.

Original languageEnglish
Patent numberWO2006089898
Filing date31/08/2006
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date22/02/2005
Priority numberGB20050003657
Publication statusPublished - 2006

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