Metabolic syndrome and subsequent risk of type 2 diabetes and cardiovascular disease in elderly women Challenging the current definition: Challenging the current definition

Katrine Dragsbæk Møller, Jesper Neergaard, Janne Marie Laursen, Henrik B. Hansen, Claus Christiansen, Henning Beck-Nielsen, Morten A. Karsdal, Susanne Brix Pedersen, Kim Henriksen

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    Abstract

    The prognostic value of the metabolic syndrome (MetS) is believed to vary with age. With an elderly population expecting to triple by 2060, it is important to evaluate the validity of MetS in this age group. We examined the association of MetS risk factors with later risk of type 2 diabetes (T2DM) and cardiovascular disease (CVD) in elderly Caucasian women. We further investigated if stratification of individuals not defined with MetS would add predictive power in defining future disease prevalence of individuals with MetS. The Prospective Epidemiological Risk Factor Study, a community-based cohort study, followed 3905 Danish women since 2000 (age: 70.1±6.5) with no previous diagnosis of T2DM or CVD, holding all measurements used for MetS definition; central obesity, hypertension, hyperlipidemia, and hyperglycemia combined with register-based follow-up information. Elderly women with defined MetS presented a 6.3-fold increased risk of T2DM (95% confidence interval: [3.74-10.50]) and 1.7-fold increased risk of CVD (1.44-2.05) compared to women with no MetS risk factors. Subdividing the control group without defined MetS revealed that both centrally obese controls and controls holding other MetS risk factors also had increased risk of T2DM (hazard ratio (HR)=2.21 [1.25-3.93] and HR=1.75 [1.04-2.96]) and CVD (HR=1.51 [1.25-1.83] and HR=1.36 [1.15-1.60]) when compared to controls with no MetS risk factors. MetS in elderly Caucasian women increased risk of future T2DM and CVD. While not defined with MetS, women holding only some risk factors for MetS were also at increased risk of T2DM or CVD compared to women with no MetS risk factors.
    Original languageEnglish
    Article numbere4806
    JournalMedicine
    Volume95
    Issue number36
    Number of pages8
    ISSN0025-7974
    DOIs
    Publication statusPublished - 2016

    Bibliographical note

    This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author.

    Keywords

    • Cardiovascular disease
    • Central obesity
    • Elderly
    • Metabolic syndrome
    • Principal component analysis
    • Type 2 diabetes

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